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Tchem
PSMB10
Proteasome subunit beta type-10

Protein Summary
Description
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358514
  • ENSP00000351314
  • ENSG00000205220

Symbol
  • LMP10
  • MECL1
  • LMP10
  • MECL1
  • beta2i
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
PubMedID
0.93
virus perturbation
0.92
protein domain
0.85
transcription factor perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.83   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.83   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 48
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (48)
CHEMBL4297468
Rendered image for CHEMBL4297468
Delanzomib
Rendered image for Delanzomib
CHEMBL4465456
Rendered image for CHEMBL4465456
CHEMBL4128898
Rendered image for CHEMBL4128898
CHEMBL4452892
Rendered image for CHEMBL4452892
CHEMBL4590398
Rendered image for CHEMBL4590398
CHEMBL4577205
Rendered image for CHEMBL4577205
CHEMBL3319481
Rendered image for CHEMBL3319481
CHEMBL4451682
Rendered image for CHEMBL4451682
CHEMBL4440581
Rendered image for CHEMBL4440581
Protein-Protein Interactions (315)
PSMB3
Tbio
Family:  Enzyme
Novelty:  0.12791198
p_int:  0.996536411
p_ni:  0.00000123
p_wrong:  0.003462358
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMA2
Tbio
Family:  Enzyme
Novelty:  0.04491574
Score:  0.999
Data Source:  STRINGDB
PSMB4
Tbio
Family:  Enzyme
Novelty:  0.0376233
Score:  0.999
Data Source:  STRINGDB
PSMA3
Tbio
Family:  Enzyme
Novelty:  0.03106507
Score:  0.999
Data Source:  STRINGDB
PSMA4
Tbio
Family:  Enzyme
Novelty:  0.04515869
Score:  0.999
Data Source:  STRINGDB
PSMB1
Tclin
Family:  Enzyme
Novelty:  0.0255917
Score:  0.999
Data Source:  STRINGDB
PSMB9
Tchem
Family:  Enzyme
Novelty:  0.0016249
Score:  0.999
Data Source:  STRINGDB
PSMA5
Tbio
Family:  Enzyme
Novelty:  0.03862668
Score:  0.999
Data Source:  STRINGDB
PSMD6
Tbio
Family:  Enzyme
Novelty:  0.04419339
Score:  0.999
Data Source:  STRINGDB
PSMA6
Tbio
Family:  Enzyme
Novelty:  0.01525994
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (162)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 148
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
18
22
38
10
99.5
apolipoprotein A 1 measurement
2
7
7
98.8
mean corpuscular volume
1
2
2
90.6
sleep duration
2
2
3
84.1
red blood cell density measurement
1
1
1
82.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
38
10
99.5
apolipoprotein A 1 measurement
7
98.8
mean corpuscular volume
2
90.6
sleep duration
3
84.1
red blood cell density measurement
1
82.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome subunit beta 10
VGNC:13783
743176
Mouse
MGI:1096380
19171
Rat
RGD:1307428
291983
Dog
proteasome subunit beta 10
489749
Horse
proteasome subunit beta 10
100066381
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome subunit beta 10
Mouse
Rat
Dog
proteasome subunit beta 10
Horse
proteasome subunit beta 10
Publication Statistics
PubMed Score 163.83
PubMed score by year
PubTator Score 53.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title