Tclin CD79B B-cell antigen receptor complex-associated protein beta chain

Protein Summary

Description

Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P40259
• Q53FS2
• Q9BU06

Gene Name

• CD79B

Ensembl ID

• ENST00000006750
• ENSP00000006750
• ENSG00000007312
• ENST00000349817
• ENSP00000245862
• ENST00000392795
• ENSP00000376544

Symbol

• B29
• IGB
• B29
• IGB
• AGM6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
PubMedID	0.72
gene perturbation	0.7
kinase perturbation	0.66
cellular component	0.62

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / B-cell Antigen Receptor Complex-associated Protein Beta Chain

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / B-cell Antigen Receptor Complex-associated Protein Beta Chain

DTO Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / B-cell Antigen Receptor Complex-associated Protein Beta Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 488.66   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 879   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 488.66   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 879   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1