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Tbio
CEACAM6
Carcinoembryonic antigen-related cell adhesion molecule 6

Protein Summary
Description
Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PubMed:2803308, PubMed:2022629, PubMed:1378450, PubMed:8776764, PubMed:11590190, PubMed:10910050, PubMed:14724575, PubMed:16204051). Intercellular adhesion occurs in a calcium- and fibronectin-independent manner (PubMed:2022629, PubMed:16204051). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (PubMed:2803308, PubMed:2022629, PubMed:8776764, PubMed:11590190, PubMed:16204051). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764). Plays a role in neutrophil adhesion to cytokine-activated endothelial cells (PubMed:1378450). Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion (PubMed:16204051). Also involved in the metastatic cascade process by inducing gain resistance to anoikis ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000199764
  • ENSP00000199764
  • ENSG00000086548

Symbol
  • NCA
  • NCA
  • CEAL
  • CD66c
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.93
gene perturbation
0.81
protein domain
0.73
small molecule perturbation
0.71
biological term
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 297.11   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 492   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 297.11   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 492   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum carcinoembryonic antigen measurement
1
1
1
43
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum carcinoembryonic antigen measurement
1
43
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Extracellular matrix organization
Reactome
Fibronectin matrix formation
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Extracellular matrix organization
Fibronectin matrix formation
Hemostasis
Immune System
Gene Ontology Terms (19)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (80)
1 – 10 of 80
CEACAM8
Tbio
Novelty: 0.00370138
Score: 0.99
Data Source: Reactome,STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.923
Data Source: STRINGDB
ITGB1
Tclin
Novelty: 0.00055626
Score: 0.917
Data Source: STRINGDB
ABCA13
Tbio
Family: Transporter
Novelty: 0.03723754
Score: 0.913
Data Source: STRINGDB
PIGR
Tbio
Novelty: 0.0025812
Score: 0.911
Data Source: STRINGDB
VNN1
Tchem
Family: Enzyme
Novelty: 0.0144646
Score: 0.91
Data Source: STRINGDB
CD63
Tchem
Novelty: 0.00072515
Score: 0.908
Data Source: STRINGDB
ITGA5
Tbio
Novelty: 0.00285802
Score: 0.908
Data Source: STRINGDB
LAMP2
Tbio
Novelty: 0.00168009
Score: 0.906
Data Source: STRINGDB
LAMP1
Tbio
Novelty: 0.00067563
Score: 0.906
Data Source: STRINGDB
Publication Statistics
PubMed Score  297.11

PubMed score by year
PubTator Score  343.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer