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Tbio
GP5
Platelet glycoprotein V

Protein Classes
Protein Summary
Description
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleedi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000401815
  • ENSP00000383931
  • ENSG00000178732

Symbol
  • GPV
  • CD42d
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.65
cell line
0.58
protein domain
0.58
transcription factor
0.52
disease
0.49


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1037.91   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1037.91   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
1
2
21.7
platelet count
1
1
1
3.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
21.7
platelet count
1
3.1
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1096363
14729
Horse
glycoprotein V platelet
VGNC:18468
100060025
Cow
glycoprotein V platelet
VGNC:29506
522692
C. elegans
179309
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Horse
glycoprotein V platelet
Cow
glycoprotein V platelet
C. elegans
Pathways (36)
Formation of Fibrin Clot (Clotting Cascade) (R-HSA-140877)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
GP1b-IX-V activation signalling
Reactome
Hemostasis
Reactome
Intrinsic Pathway of Fibrin Clot Formation
Reactome
Platelet Adhesion to exposed collagen
Name
Explore in Pharos
Explore in Source
Formation of Fibrin Clot (Clotting Cascade)
GP1b-IX-V activation signalling
Hemostasis
Intrinsic Pathway of Fibrin Clot Formation
Platelet Adhesion to exposed collagen
Protein-Protein Interactions (75)
1 – 10 of 75
GP9
Tbio
Novelty: 0.00365769
Score: 0.993
Data Source: Reactome,STRINGDB
GP1BB
Tbio
Novelty: 0.01235173
Score: 0.982
Data Source: Reactome,STRINGDB
VWF
Tbio
Novelty: 0.00009007
Score: 0.974
Data Source: Reactome,STRINGDB
GP1BA
Tbio
Novelty: 0.00138736
Score: 0.956
Data Source: Reactome,STRINGDB
YWHAZ
Tbio
Novelty: 0.00210582
Score: 0.953
Data Source: Reactome,STRINGDB
SERPIND1
Tbio
Novelty: 0.00120897
Score: 0.951
Data Source: STRINGDB
F2
Tclin
Family: Enzyme
Novelty: 0.00004833
Score: 0.947
Data Source: Reactome,STRINGDB
F8
Tbio
Novelty: 0.0002287
Score: 0.944
Data Source: STRINGDB
GP6
Tbio
Novelty: 0.0010722
Score: 0.925
Data Source: STRINGDB
SERPINC1
Tclin
Novelty: 0.00008721
Score: 0.923
Data Source: STRINGDB
Publication Statistics
PubMed Score  1037.91

PubMed score by year
PubTator Score  330.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer