Tbio DCT L-dopachrome tautomerase

Protein Summary

Description

Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA) (PubMed:8306979). Involved in regulating eumelanin and phaeomelanin levels.

Uniprot Accession IDs

• P40126
• Q09GT4
• DCT

Gene Name

• DCT

Ensembl ID

• ENST00000377028
• ENSP00000366227
• ENSG00000080166
• ENST00000446125
• ENSP00000392762

Symbol

• TYRP2
• TRP-2
• TYRP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.88
gene perturbation	0.77
cell type or tissue	0.7
disease	0.64
biological process	0.63

Protein Classes

PANTHER Classes

Protein / ... / Oxygenase / L-dopachrome Tautomerase

Protein / ... / Oxidase / L-dopachrome Tautomerase

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxygenase / L-dopachrome Tautomerase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.94   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 381   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.94   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 381   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0