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Tbio
CAP2
Adenylyl cyclase-associated protein 2

Protein Summary
Description
May have a regulatory bifunctional role. This gene was identified by its similarity to the gene for human adenylyl cyclase-associated protein. The function of the protein encoded by this gene is unknown. However, the protein appears to be able to interact with adenylyl cyclase-associated protein and actin. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229922
  • ENSP00000229922
  • ENSG00000112186
  • ENST00000465994
  • ENSP00000418604
  • ENST00000493172
  • ENSP00000417208
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
PubMedID
0.87
transcription factor perturbation
0.84
hub protein
0.75
gene perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.39   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.39   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (7)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Role of ABL in ROBO-SLIT signaling
Reactome
Signaling by ROBO receptors
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Role of ABL in ROBO-SLIT signaling
Signaling by ROBO receptors
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (126)
1 – 10 of 126
CAP1
Tbio
Family: Enzyme
Novelty: 0.03666609
p_int: 0.999999686
p_ni: 3.14e-7
Score: 0.926
Data Source: BioPlex,STRINGDB
POTEI
Tdark
Novelty: 0.30601093
p_int: 0.999988398
p_ni: 0.000011602
Score: 0.623
Data Source: BioPlex,STRINGDB
TWF2
Tbio
Novelty: 0.05199307
p_int: 0.999961518
p_ni: 0.000038482
Score: 0.904
Data Source: BioPlex,STRINGDB
BCL7A
Tbio
Novelty: 0.09319798
p_int: 0.999933799
p_ni: 0.000066201
Score: 0.555
Data Source: BioPlex,STRINGDB
CFL1
Tbio
Novelty: 0.00066971
p_int: 0.999720318
p_ni: 0.000279682
Score: 0.927
Data Source: BioPlex,STRINGDB
BCL7C
Tdark
Novelty: 0.55480559
p_int: 0.999503483
p_ni: 0.000496517
Score: 0.741
Data Source: BioPlex,STRINGDB
ACTA2
Tbio
Novelty: 0.00281551
p_int: 0.99788665
p_ni: 0.002113334
p_wrong: 1.7e-8
Score: 0.839
Data Source: BioPlex,STRINGDB
ACTBL2
Tbio
Novelty: 0.35273907
p_int: 0.995253433
p_ni: 0.004746567
Score: 0.624
Data Source: BioPlex,STRINGDB
ACTB
Tbio
Novelty: 0.00027728
p_int: 0.983804305
p_ni: 0.016195696
Score: 0.777
Data Source: BioPlex,STRINGDB
GRXCR1
Tdark
Novelty: 0.27456258
Score: 0.943
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.39

PubMed score by year
PubTator Score  55.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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