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Tbio
CAP2
Adenylyl cyclase-associated protein 2

Protein Summary
Description
May have a regulatory bifunctional role. This gene was identified by its similarity to the gene for human adenylyl cyclase-associated protein. The function of the protein encoded by this gene is unknown. However, the protein appears to be able to interact with adenylyl cyclase-associated protein and actin. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229922
  • ENSP00000229922
  • ENSG00000112186
  • ENST00000465994
  • ENSP00000418604
  • ENST00000493172
  • ENSP00000417208
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
PubMedID
0.87
transcription factor perturbation
0.84
hub protein
0.75
gene perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.75   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.75   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
CAP1
Tbio
Family:  Enzyme
Novelty:  0.0333464
p_int:  0.999999686
p_ni:  3.14e-7
Score:  0.926
Data Source:  BioPlex,STRINGDB
POTEI
Tdark
Novelty:  0.41311202
p_int:  0.999988398
p_ni:  0.000011602
Score:  0.623
Data Source:  BioPlex,STRINGDB
TWF2
Tbio
Novelty:  0.0419582
p_int:  0.999961518
p_ni:  0.000038482
Score:  0.904
Data Source:  BioPlex,STRINGDB
BCL7A
Tbio
Novelty:  0.07026394
p_int:  0.999933799
p_ni:  0.000066201
Score:  0.555
Data Source:  BioPlex,STRINGDB
CFL1
Tbio
Novelty:  0.00071544
p_int:  0.999720318
p_ni:  0.000279682
Score:  0.927
Data Source:  BioPlex,STRINGDB
BCL7C
Tdark
Novelty:  0.31203802
p_int:  0.999503483
p_ni:  0.000496517
Score:  0.741
Data Source:  BioPlex,STRINGDB
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.99788665
p_ni:  0.002113334
p_wrong:  1.7e-8
Score:  0.839
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.995253433
p_ni:  0.004746567
Score:  0.624
Data Source:  BioPlex,STRINGDB
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.983804305
p_ni:  0.016195696
Score:  0.777
Data Source:  BioPlex,STRINGDB
GRXCR1
Tdark
Novelty:  0.17455124
Score:  0.943
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Role of ABL in ROBO-SLIT signaling
Reactome
Signaling by ROBO receptors
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Role of ABL in ROBO-SLIT signaling
Signaling by ROBO receptors
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
1
2
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclase associated actin cytoskeleton regulatory protein 2
VGNC:14844
462454
Macaque
cyclase associated actin cytoskeleton regulatory protein 2
703445
Mouse
MGI:1914502
67252
Rat
RGD:620310
116653
Dog
cyclase associated actin cytoskeleton regulatory protein 2
VGNC:38696
478731
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclase associated actin cytoskeleton regulatory protein 2
Macaque
cyclase associated actin cytoskeleton regulatory protein 2
Mouse
Rat
Dog
cyclase associated actin cytoskeleton regulatory protein 2
Publication Statistics
PubMed Score 4.75
PubMed score by year
PubTator Score 55.46
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title