You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
P3H2
Prolyl 3-hydroxylase 2

Protein Summary
Description
Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens (PubMed:18487197). Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1 (PubMed:18487197). Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline (PubMed:18487197). Has no activity on substrates that lack 4-hydroxyproline in the third position (PubMed:18487197). This gene encodes a member of the prolyl 3-hydroxylase subfamily of 2-oxo-glutarate-dependent dioxygenases. These enzymes play a critical role in collagen chain assembly, stability and cross-linking by catalyzing post-translational 3-hydroxylation of proline residues. Mutations in this gene are associated with nonsyndromic severe myopia with cataract and vitreoretinal degeneration, and downregulation of this gene may pl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319332
  • ENSP00000316881
  • ENSG00000090530
  • ENST00000427335
  • ENSP00000408947

Symbol
  • LEPREL1
  • MLAT4
  • MCVD
  • MLAT4
  • LEPREL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.83
molecular function
0.81
tissue sample
0.73
transcription factor perturbation
0.68
tissue
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.8   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.8   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
ZNF232
Tdark
Family:  TF
Novelty:  0.68288358
p_int:  0.999999868
p_ni:  1.32e-7
Data Source:  BioPlex
ZNF219
Tbio
Family:  TF
Novelty:  0.17515242
p_int:  0.999999801
p_ni:  1.98e-7
Score:  0.186
Data Source:  BioPlex,STRINGDB
BGLAP
Tbio
Novelty:  0.00009678
p_int:  0.999998788
p_ni:  0.000001212
Data Source:  BioPlex
KRBA1
Tdark
Novelty:  2.59384945
p_int:  0.999997627
p_ni:  0.000002353
p_wrong:  2e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
COLQ
Tbio
Family:  Enzyme
Novelty:  0.01414634
p_int:  0.999997452
p_ni:  0.000002539
p_wrong:  1e-8
Score:  0.166
Data Source:  BioPlex,STRINGDB
ALX3
Tbio
Family:  TF
Novelty:  0.02711914
p_int:  0.999997058
p_ni:  0.000002942
Score:  0.158
Data Source:  BioPlex,STRINGDB
EDA
Tbio
Novelty:  0.00352464
p_int:  0.999977156
p_ni:  0.000017498
p_wrong:  0.000005346
Data Source:  BioPlex
FEZF1
Tbio
Family:  TF
Novelty:  0.01942826
p_int:  0.999913454
p_ni:  0.000086004
p_wrong:  5.42e-7
Data Source:  BioPlex
RBMX
Tbio
Novelty:  0.01705784
p_int:  0.999073394
p_ni:  0.000831761
p_wrong:  0.000094845
Score:  0.191
Data Source:  BioPlex,STRINGDB
ZNF74
Tbio
Family:  TF
Novelty:  0.10554307
p_int:  0.998874713
p_ni:  0.000408874
p_wrong:  0.000716414
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen formation
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
58.3
platelet count
2
2
2
50.8
heart septal defect
1
1
0
3
48.8
urinary bladder carcinoma
2
1
0
1.2
23.6
1
1
0
1.2
9.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
58.3
platelet count
2
50.8
heart septal defect
0
3
48.8
urinary bladder carcinoma
0
1.2
23.6
0
1.2
9.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prolyl 3-hydroxylase 2
VGNC:7086
740124
Macaque
prolyl 3-hydroxylase 2
704118
Mouse
MGI:2146663
210530
Dog
prolyl 3-hydroxylase 2
VGNC:44220
478674
Horse
prolyl 3-hydroxylase 2
VGNC:21114
100059777
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prolyl 3-hydroxylase 2
Macaque
prolyl 3-hydroxylase 2
Mouse
Dog
prolyl 3-hydroxylase 2
Horse
prolyl 3-hydroxylase 2
Publication Statistics
PubMed Score 34.80
PubMed score by year
PubTator Score 27.57
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title