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Tbio
P39880
Homeobox protein cut-like 1

Protein Summary
Description
Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator (By similarity). The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292535
  • ENSP00000292535
  • ENSG00000257923
  • ENST00000360264
  • ENSP00000353401
  • ENST00000425244
  • ENSP00000409745
  • ENST00000546411
  • ENSP00000450125
  • ENST00000549414
  • ENSP00000446630
  • ENST00000550008
  • ENSP00000447373
  • ENST00000556210
  • ENSP00000451558

Symbol
  • CUTL1
  • CDP
  • CUX
  • p75
  • CASP
  • CDP1
  • COY1
  • Clox
  • GDDI
  • p100
  • p110
  • p200
  • CUTL1
  • GOLIM6
  • CDP/Cut
  • Cux/CDP
  • Nbla10317
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
transcription factor binding site profile
0.95
transcription factor
0.86
biological process
0.85
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 378.1   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 368   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 378.1   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (175)
NDUFB8
Tclin
Family:  Enzyme
Novelty:  0.019021
p_int:  0.99986415
p_ni:  0.000135851
Data Source:  BioPlex
STX6
Tbio
Novelty:  0.01494028
p_int:  0.998145217
p_ni:  0.001854782
Score:  0.271
Data Source:  BioPlex,STRINGDB
JTB
Tbio
Novelty:  0.06646216
p_int:  0.996086324
p_ni:  0.003913676
Data Source:  BioPlex
SLC39A4
Tbio
Family:  Transporter
Novelty:  0.00742159
p_int:  0.992028945
p_ni:  0.007971052
p_wrong:  3e-9
Data Source:  BioPlex
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
p_int:  0.988432566
p_ni:  0.011567434
Data Source:  BioPlex
HLA-DQA1
Tbio
Novelty:  0.00077488
p_int:  0.985380763
p_ni:  0.014619235
p_wrong:  2e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
EXT2
Tbio
Family:  Enzyme
Novelty:  0.00480574
p_int:  0.984977607
p_ni:  0.015022393
Score:  0.221
Data Source:  BioPlex,STRINGDB
RAB30
Tbio
Family:  Enzyme
Novelty:  0.1262404
p_int:  0.975151644
p_ni:  0.024848356
Data Source:  BioPlex
MAGEA10
Tbio
Novelty:  0.05364393
p_int:  0.966552622
p_ni:  0.033447378
Data Source:  BioPlex
NUP62
Tbio
Novelty:  0.01432724
p_int:  0.9556669
p_ni:  0.0443331
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FGFR1 mutant receptor activation
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
FGFR1 mutant receptor activation
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
10
97.4
platelet crit
2
2
6
92.5
sex hormone-binding globulin measurement
6
2
12
83
eosinophil count
2
3
6
79.3
chronotype measurement
2
2
4
1
74
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
10
97.4
platelet crit
6
92.5
sex hormone-binding globulin measurement
12
83
eosinophil count
6
79.3
chronotype measurement
4
1
74
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cut like homeobox 1
VGNC:13642
450166
Macaque
cut-like homeobox 1
574390
Rat
RGD:620618
116639
Dog
cut like homeobox 1
VGNC:39738
489821
Opossum
cut like homeobox 1
100028646
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cut like homeobox 1
Macaque
cut-like homeobox 1
Rat
Dog
cut like homeobox 1
Opossum
cut like homeobox 1
Publication Statistics
PubMed Score 378.10
PubMed score by year
PubTator Score 1088.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title