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Tbio
P39880
Homeobox protein cut-like 1

Protein Summary
Description
Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator (By similarity). The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292535
  • ENSP00000292535
  • ENSG00000257923
  • ENST00000360264
  • ENSP00000353401
  • ENST00000425244
  • ENSP00000409745
  • ENST00000546411
  • ENSP00000450125
  • ENST00000549414
  • ENSP00000446630
  • ENST00000550008
  • ENSP00000447373
  • ENST00000556210
  • ENSP00000451558

Symbol
  • CUTL1
  • CDP
  • CUX
  • p75
  • CASP
  • CDP1
  • COY1
  • Clox
  • GDDI
  • p100
  • p110
  • p200
  • CUTL1
  • GOLIM6
  • CDP/Cut
  • Cux/CDP
  • Nbla10317
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
transcription factor binding site profile
0.95
transcription factor
0.86
biological process
0.85
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 577.48   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 368   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 577.48   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0