Tchem PLA2G5 Calcium-dependent phospholipase A2

Protein Summary

Description

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle. This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P39877
• Q8N435

Gene Name

• PLA2G5

Ensembl ID

• ENST00000375108
• ENSP00000364249
• ENSG00000127472

Symbol

• FRFB
• GV-PLA2
• PLA2-10
• hVPLA(2)

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	0.95
biological process	0.91
cell type or tissue	0.71
molecular function	0.67
gene perturbation	0.6

Protein Classes

PANTHER Classes

Protein / Hydrolase / Lipase / Phospholipase / Calcium-dependent Phospholipase A2

DTO Classes

Protein / Enzyme / Hydrolase / Lipase / Phospholipase / Calcium-dependent Phospholipase A2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.81   (req: < 5)

Gene RIFs: 32   (req: <= 3)

Antibodies: 157   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.81   (req: >= 5)

Gene RIFs: 32   (req: > 3)

Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 20

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0