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Tchem
PLA2G5
Calcium-dependent phospholipase A2

Protein Summary
Description
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle. This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been fo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375108
  • ENSP00000364249
  • ENSG00000127472

Symbol
  • FRFB
  • GV-PLA2
  • PLA2-10
  • hVPLA(2)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.95
biological process
0.91
cell type or tissue
0.71
molecular function
0.67
gene perturbation
0.6


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.41   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.41   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group V
VGNC:9883
456588
Mouse
MGI:101899
18784
Rat
RGD:62051
29354
Dog
phospholipase A2 group V
VGNC:44630
478207
Horse
phospholipase A2 group V
VGNC:21517
100058536
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group V
Mouse
Rat
Dog
phospholipase A2 group V
Horse
phospholipase A2 group V
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P39877-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (25)
Acyl chain remodelling of PC (R-HSA-1482788)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Acyl chain remodelling of PG
Reactome
Acyl chain remodelling of PI
Reactome
Acyl chain remodelling of PS
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PG
Acyl chain remodelling of PI
Acyl chain remodelling of PS
Gene Ontology Terms (30)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (76)
1 – 10 of 76
PLA2G4D
Tbio
Family: Enzyme
Novelty: 0.15982255
Score: 0.905
Data Source: STRINGDB
PLA2G4A
Tchem
Family: Enzyme
Novelty: 0.00158329
Score: 0.826
Data Source: STRINGDB
PLD1
Tchem
Family: Enzyme
Novelty: 0.00608142
Score: 0.799
Data Source: STRINGDB
PLA2G15
Tbio
Family: Enzyme
Novelty: 0.01546393
Score: 0.795
Data Source: STRINGDB
PTGS2
Tclin
Family: Enzyme
Novelty: 0.00007089
Score: 0.771
Data Source: STRINGDB
PLA2G16
Tbio
Novelty: 0.02310886
Score: 0.765
Data Source: STRINGDB
ALOX5
Tclin
Family: Enzyme
Novelty: 0.00062988
Score: 0.756
Data Source: STRINGDB
PLA2G7
Tchem
Family: Enzyme
Novelty: 0.00270949
Score: 0.753
Data Source: STRINGDB
PTGS1
Tclin
Family: Enzyme
Novelty: 0.00043214
Score: 0.74
Data Source: STRINGDB
ALOX15
Tchem
Family: Enzyme
Novelty: 0.00184734
Score: 0.731
Data Source: STRINGDB
Publication Statistics
PubMed Score  36.41

PubMed score by year
PubTator Score  42.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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