Protein Classes
Protein Summary
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Oka ...more
- ENST00000305885
- ENSP00000305480
- ENSG00000168496
- RAD2
- MF1
- RAD2
- FEN-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.99 | ||
molecular function | 0.98 | ||
kinase perturbation | 0.97 | ||
co-expressed gene | 0.93 | ||
protein domain | 0.92 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1233.33 (req: < 5)
Gene RIFs: 106 (req: <= 3)
Antibodies: 522 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1233.33 (req: >= 5)
Gene RIFs: 106 (req: > 3)
Antibodies: 522 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 35
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (35)
1 – 10 of 35
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
docosapentaenoic acid measurement | 2 | 1 | 2 | 91.9 | |||||
alpha-linolenic acid measurement | 1 | 1 | 1 | 88 | |||||
eicosapentaenoic acid measurement | 1 | 1 | 1 | 85.7 | |||||
trans fatty acid measurement | 1 | 1 | 1 | 84.4 | |||||
1 | 1 | 0 | 1.1 | 57.2 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
docosapentaenoic acid measurement | 2 | 91.9 | |||||
alpha-linolenic acid measurement | 1 | 88 | |||||
eicosapentaenoic acid measurement | 1 | 85.7 | |||||
trans fatty acid measurement | 1 | 84.4 | |||||
0 | 1.1 | 57.2 | |||||
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | flap structure-specific endonuclease 1 | VGNC:6752 | 451242 | |||||
Macaque | flap structure-specific endonuclease 1 | 722348 | ||||||
Mouse | MGI:102779 | 14156 | ||||||
Rat | RGD:621821 | 84490 | ||||||
Dog | flap structure-specific endonuclease 1 | VGNC:40817 | 476063 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | flap structure-specific endonuclease 1 | |||||
Macaque | flap structure-specific endonuclease 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | flap structure-specific endonuclease 1 | |||||
Protein Structure (11 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 11
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (33)
Reactome (29)
KEGG (3)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 29
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Base Excision Repair | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Chromosome Maintenance | ||||
Reactome | DNA Double-Strand Break Repair | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Base Excision Repair | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Chromosome Maintenance | ||||
DNA Double-Strand Break Repair | ||||
Gene Ontology Terms (33)
Functions (14)
Components (7)
Processes (12)
Items per page:
10
1 – 10 of 14
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (410)
1 – 10 of 410
PCNA
Novelty: 0.03909539
p_int: 0.999924849
p_ni: 0.000075151
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SNRNP27
Novelty: 0.0175187
p_int: 0.994826868
p_ni: 0.005173132
Score: 0.167
Data Source: BioPlex,STRINGDB
GTF2E2
Novelty: 0.18033153
p_int: 0.983600845
p_ni: 0.016399105
p_wrong: 5e-8
Score: 0.249
Data Source: BioPlex,STRINGDB
FGB
Novelty: 0.00437751
p_int: 0.963137954
p_ni: 0.036861984
p_wrong: 6.3e-8
Data Source: BioPlex
DUSP19
Family: Enzyme
Novelty: 0.13289846
p_int: 0.942701965
p_ni: 0.057297789
p_wrong: 2.46e-7
Score: 0.315
Data Source: BioPlex,STRINGDB
USP47
Family: Enzyme
Novelty: 0.07579226
p_int: 0.923865259
p_ni: 0.076050725
p_wrong: 0.000084016
Score: 0.203
Data Source: BioPlex,STRINGDB
FAM24B
Novelty: 1.04675689
p_int: 0.916054498
p_ni: 0.083945338
p_wrong: 1.64e-7
Data Source: BioPlex
ACTL6A
Novelty: 0.01892162
p_int: 0.910419609
p_ni: 0.08958039
p_wrong: 1e-9
Score: 0.394
Data Source: BioPlex,STRINGDB
PTCRA
Novelty: 0.01307489
p_int: 0.858701917
p_ni: 0.141298082
Score: 0.309
Data Source: BioPlex,STRINGDB
LIG1
Family: Enzyme
Novelty: 0.00326816
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score 1233.33
PubMed score by year
PubTator Score 389.82
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by:
UniProt Keyword
GWAS Trait