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Tchem
FEN1
Flap endonuclease 1

Protein Summary
Description
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Oka ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305885
  • ENSP00000305480
  • ENSG00000168496

Symbol
  • RAD2
  • MF1
  • RAD2
  • FEN-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
molecular function
0.98
kinase perturbation
0.97
co-expressed gene
0.93
protein domain
0.92


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1247.13   (req: < 5)
Gene RIFs: 106   (req: <= 3)
Antibodies: 522   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1247.13   (req: >= 5)
Gene RIFs: 106   (req: > 3)
Antibodies: 522   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 35
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (35)
CHEMBL361962
Rendered image for CHEMBL361962
CHEMBL361011
Rendered image for CHEMBL361011
CHEMBL359533
Rendered image for CHEMBL359533
CHEMBL183133
Rendered image for CHEMBL183133
CHEMBL361350
Rendered image for CHEMBL361350
CHEMBL182381
Rendered image for CHEMBL182381
CHEMBL364591
Rendered image for CHEMBL364591
CHEMBL183792
Rendered image for CHEMBL183792
CHEMBL182687
Rendered image for CHEMBL182687
Protein-Protein Interactions (410)
PCNA
Tchem
Novelty:  0.03909539
p_int:  0.999924849
p_ni:  0.000075151
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.994826868
p_ni:  0.005173132
Score:  0.167
Data Source:  BioPlex,STRINGDB
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.983600845
p_ni:  0.016399105
p_wrong:  5e-8
Score:  0.249
Data Source:  BioPlex,STRINGDB
FGB
Tbio
Novelty:  0.00437751
p_int:  0.963137954
p_ni:  0.036861984
p_wrong:  6.3e-8
Data Source:  BioPlex
DUSP19
Tbio
Family:  Enzyme
Novelty:  0.13289846
p_int:  0.942701965
p_ni:  0.057297789
p_wrong:  2.46e-7
Score:  0.315
Data Source:  BioPlex,STRINGDB
USP47
Tchem
Family:  Enzyme
Novelty:  0.07579226
p_int:  0.923865259
p_ni:  0.076050725
p_wrong:  0.000084016
Score:  0.203
Data Source:  BioPlex,STRINGDB
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.916054498
p_ni:  0.083945338
p_wrong:  1.64e-7
Data Source:  BioPlex
ACTL6A
Tbio
Novelty:  0.01892162
p_int:  0.910419609
p_ni:  0.08958039
p_wrong:  1e-9
Score:  0.394
Data Source:  BioPlex,STRINGDB
PTCRA
Tbio
Novelty:  0.01307489
p_int:  0.858701917
p_ni:  0.141298082
Score:  0.309
Data Source:  BioPlex,STRINGDB
LIG1
Tchem
Family:  Enzyme
Novelty:  0.00326816
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (33)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Chromosome Maintenance
Reactome
DNA Double-Strand Break Repair
Name
Explore in Pharos
Explore in Source
Base Excision Repair
Cell Cycle
Cell Cycle, Mitotic
Chromosome Maintenance
DNA Double-Strand Break Repair
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (122)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
5
17
43
99.9
docosapentaenoic acid measurement
2
13
16
99.8
high density lipoprotein cholesterol measurement
15
23
40
1.9
99.8
serum metabolite measurement
7
47
292
99.8
linoleic acid measurement
2
9
10
99.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
43
99.9
docosapentaenoic acid measurement
16
99.8
high density lipoprotein cholesterol measurement
40
1.9
99.8
serum metabolite measurement
292
99.8
linoleic acid measurement
10
99.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
flap structure-specific endonuclease 1
VGNC:6752
451242
Macaque
flap structure-specific endonuclease 1
722348
Mouse
MGI:102779
14156
Rat
RGD:621821
84490
Dog
flap structure-specific endonuclease 1
VGNC:40817
476063
Species
Name
OMA
EggNOG
Inparanoid
Chimp
flap structure-specific endonuclease 1
Macaque
flap structure-specific endonuclease 1
Mouse
Rat
Dog
flap structure-specific endonuclease 1
Publication Statistics
PubMed Score 1247.13
PubMed score by year
PubTator Score 389.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title