Protein Summary
Involved in mitochondria homeostasis. May be involved in the metabolism of reactive oxygen species and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance. This gene encodes a mitochondrial inner membrane protein that is implicated in the metabolism of reactive oxygen species. Mutations in this gene have been associated with the hepatocerebral form of mitochondrial DNA depletion syndrome (MDDS). [provided by RefSeq, Jul 2008]
- ENST00000233545
- ENSP00000233545
- ENSG00000115204
- ENST00000380044
- ENSP00000369383
- SYM1
- MTDPS6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.91 | ||
virus perturbation | 0.85 | ||
cellular component | 0.79 | ||
transcription factor perturbation | 0.68 | ||
transcription factor binding site profile | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.89 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 164 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.89 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 164 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (108)
Nearest Tclin Targets
Pathways (3)
Reactome (2)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Peroxisomal protein import | ||||
Reactome | Protein localization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Peroxisomal protein import | ||||
Protein localization | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Components (7)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (27)
Items per page:
1 – 5 of 27
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 10 | 19 | 31 | 99.9 | |||||
C-reactive protein measurement | 2 | 7 | 7 | 98.2 | |||||
total cholesterol measurement | 2 | 5 | 4 | 3.9 | 96.1 | ||||
serum gamma-glutamyl transferase measurement | 1 | 4 | 4 | 96 | |||||
urate measurement | 1 | 4 | 4 | 95.6 | |||||
Items per page:
1 – 5 of 27
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
triglyceride measurement | 31 | 99.9 | |||||
C-reactive protein measurement | 7 | 98.2 | |||||
total cholesterol measurement | 4 | 3.9 | 96.1 | ||||
serum gamma-glutamyl transferase measurement | 4 | 96 | |||||
urate measurement | 4 | 95.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | MPV17, mitochondrial inner membrane protein | VGNC:306 | 100610193 | |||||
Macaque | protein Mpv17 [Source:RefSeq peptide;Acc:NP_001247906] | |||||||
Mouse | MGI:97138 | 17527 | ||||||
Rat | RGD:1310512 | 360463 | ||||||
Dog | MPV17, mitochondrial inner membrane protein | 611056 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | MPV17, mitochondrial inner membrane protein | |||||
Macaque | protein Mpv17 [Source:RefSeq peptide;Acc:NP_001247906] | |||||
Mouse | ||||||
Rat | ||||||
Dog | MPV17, mitochondrial inner membrane protein | |||||
Publication Statistics
PubMed Score 58.89
PubMed score by year
PubTator Score 52.64
PubTator score by year
Related Publications
Text Mined References (32)
GeneRif Annotations (19)
Items per page:
0 of 0
PMID | Year | Title |
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