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Tbio
MPV17
Protein Mpv17

Protein Summary
Description
Involved in mitochondria homeostasis. May be involved in the metabolism of reactive oxygen species and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance. This gene encodes a mitochondrial inner membrane protein that is implicated in the metabolism of reactive oxygen species. Mutations in this gene have been associated with the hepatocerebral form of mitochondrial DNA depletion syndrome (MDDS). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233545
  • ENSP00000233545
  • ENSG00000115204
  • ENST00000380044
  • ENSP00000369383

Symbol
  • SYM1
  • MTDPS6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
virus perturbation
0.85
cellular component
0.79
transcription factor perturbation
0.68
transcription factor binding site profile
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.89   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.89   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
CLUH
Tbio
Novelty:  0.14027296
p_int:  0.92066729
p_ni:  0.07933271
Data Source:  BioPlex
CAT
Tbio
Family:  Enzyme
Novelty:  0.00181888
Score:  0.921
Data Source:  STRINGDB
HSD17B4
Tbio
Novelty:  0.00547499
Score:  0.919
Data Source:  STRINGDB
TYSND1
Tbio
Family:  Enzyme
Novelty:  0.16036122
Score:  0.916
Data Source:  STRINGDB
SCP2
Tchem
Novelty:  0.00183736
Score:  0.914
Data Source:  STRINGDB
AGXT
Tbio
Family:  Enzyme
Novelty:  0.00267512
Score:  0.912
Data Source:  STRINGDB
AMACR
Tbio
Family:  Enzyme
Novelty:  0.00218306
Score:  0.909
Data Source:  STRINGDB
GSTK1
Tchem
Family:  Enzyme
Novelty:  0.04205366
Score:  0.908
Data Source:  STRINGDB
DDO
Tchem
Family:  Enzyme
Novelty:  0.02519366
Score:  0.907
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.907
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Peroxisomal protein import (R-HSA-9033241)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Peroxisomal protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Peroxisomal protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
10
19
31
99.9
C-reactive protein measurement
2
7
7
98.2
total cholesterol measurement
2
5
4
3.9
96.1
serum gamma-glutamyl transferase measurement
1
4
4
96
urate measurement
1
4
4
95.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
31
99.9
C-reactive protein measurement
7
98.2
total cholesterol measurement
4
3.9
96.1
serum gamma-glutamyl transferase measurement
4
96
urate measurement
4
95.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MPV17, mitochondrial inner membrane protein
VGNC:306
100610193
Macaque
protein Mpv17 [Source:RefSeq peptide;Acc:NP_001247906]
Mouse
MGI:97138
17527
Rat
RGD:1310512
360463
Dog
MPV17, mitochondrial inner membrane protein
611056
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MPV17, mitochondrial inner membrane protein
Macaque
protein Mpv17 [Source:RefSeq peptide;Acc:NP_001247906]
Mouse
Rat
Dog
MPV17, mitochondrial inner membrane protein
Publication Statistics
PubMed Score 58.89
PubMed score by year
PubTator Score 52.64
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title