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Tbio
COL18A1
Collagen alpha-1(XVIII) chain

Protein Summary
Description
Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Non-collagenous domain 1: May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling. Endostatin: Potently inhibits endothelial cell proliferation and angiogenesis (PubMed:9459295). May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (By similarity). Inhibits VEGFA-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (By similarity). May negatively regulate the activity of homotrimeric non-collagenous domain 1 (PubMed:11257123). This gene enco ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355480
  • ENSP00000347665
  • ENSG00000182871
  • ENST00000359759
  • ENSP00000352798
  • ENST00000400337
  • ENSP00000383191

Symbol
  • KS
  • KNO
  • KNO1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
transcription factor perturbation
0.98
PubMedID
0.97
disease perturbation
0.95
biological term
0.89


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1398.05   (req: < 5)
Gene RIFs: 132   (req: <= 3)
Antibodies: 545   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1398.05   (req: >= 5)
Gene RIFs: 132   (req: > 3)
Antibodies: 545   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
1
3
86.7
exercise test
1
1
0
20.6
39.9
apolipoprotein A 1 measurement
1
1
1
38.5
high density lipoprotein cholesterol measurement
1
1
1
28.2
total cholesterol measurement
1
1
1
24.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
86.7
exercise test
0
20.6
39.9
apolipoprotein A 1 measurement
1
38.5
high density lipoprotein cholesterol measurement
1
28.2
total cholesterol measurement
1
24.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collagen type XVIII alpha 1 chain
VGNC:10689
474050
Mouse
MGI:88451
12822
Rat
RGD:70936
85251
Dog
collagen type XVIII alpha 1 chain
VGNC:49781
100687767
Horse
collagen type XVIII alpha 1 chain
VGNC:16728
100055712
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collagen type XVIII alpha 1 chain
Mouse
Rat
Dog
collagen type XVIII alpha 1 chain
Horse
collagen type XVIII alpha 1 chain
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P39060-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen degradation
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen degradation
Gene Ontology Terms (24)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (188)
1 – 10 of 188
PLOD1
Tbio
Family: Enzyme
Novelty: 0.00905345
p_int: 0.999981676
p_ni: 0.000018324
Score: 0.921
Data Source: BioPlex,STRINGDB
LAIR2
Tbio
Novelty: 0.06117644
p_int: 0.999943005
p_ni: 0.000056995
Data Source: BioPlex
MMP2
Tchem
Family: Enzyme
Novelty: 0.00012762
p_int: 0.999641796
p_ni: 0.000358203
Score: 0.985
Data Source: BioPlex,STRINGDB
PLOD3
Tbio
Family: Enzyme
Novelty: 0.02211629
p_int: 0.999048948
p_ni: 0.000951052
Score: 0.905
Data Source: BioPlex,STRINGDB
SIAE
Tbio
Family: Enzyme
Novelty: 0.01138067
p_int: 0.997863846
p_ni: 0.002136154
Data Source: BioPlex
P4HA1
Tchem
Family: Enzyme
Novelty: 0.01624726
p_int: 0.997730211
p_ni: 0.002269789
Score: 0.905
Data Source: BioPlex,STRINGDB
CRP
Tbio
Novelty: 0.00001517
p_int: 0.996888559
p_ni: 0.003111424
p_wrong: 1.6e-8
Score: 0.309
Data Source: BioPlex,STRINGDB
MMP9
Tchem
Family: Enzyme
Novelty: 0.00008645
p_int: 0.996309126
p_ni: 0.003690874
Score: 0.964
Data Source: BioPlex,STRINGDB
DEFA1
Tbio
Novelty: 0.01027492
p_int: 0.994468823
p_ni: 0.005531176
Score: 0.18
Data Source: BioPlex,STRINGDB
SFTPA2
Tbio
Novelty: 0.00283745
p_int: 0.958235906
p_ni: 0.041764094
Data Source: BioPlex
Publication Statistics
PubMed Score  1398.05

PubMed score by year
PubTator Score  854.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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