COL15A1
Collagen alpha-1(XV) chain
Protein Summary
Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle. Restin potently inhibits angiogenesis. This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. [provided by RefSeq, May 2013]
- ENST00000375001
- ENSP00000364140
- ENSG00000204291
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
gene perturbation | 0.81 | ||
PubMedID | 0.81 | ||
small molecule perturbation | 0.65 | ||
cell line | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.88 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 123 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.88 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 123 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (92)
Nearest Tclin Targets
Pathways (10)
Reactome (7)
KEGG (1)
PathwayCommons (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Assembly of collagen fibrils and other multimeric structures | ||||
Reactome | Collagen biosynthesis and modifying enzymes | ||||
Reactome | Collagen chain trimerization | ||||
Reactome | Collagen degradation | ||||
Reactome | Collagen formation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Assembly of collagen fibrils and other multimeric structures | ||||
Collagen biosynthesis and modifying enzymes | ||||
Collagen chain trimerization | ||||
Collagen degradation | ||||
Collagen formation | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (2)
Components (8)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
pulse pressure measurement | 1 | 1 | 1 | 75.9 | |||||
BMI-adjusted waist circumference | 1 | 3 | 3 | 67.8 | |||||
2 | 2 | 0 | 1.1 | 60.4 | |||||
2 | 2 | 0 | 1.1 | 51.4 | |||||
waist-hip ratio | 1 | 1 | 1 | 42.3 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
pulse pressure measurement | 1 | 75.9 | |||||
BMI-adjusted waist circumference | 3 | 67.8 | |||||
0 | 1.1 | 60.4 | |||||
0 | 1.1 | 51.4 | |||||
waist-hip ratio | 1 | 42.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | collagen type XV alpha 1 chain | VGNC:10680 | 464611 | |||||
Macaque | collagen type XV alpha 1 chain | 715003 | ||||||
Mouse | MGI:88449 | 12819 | ||||||
Rat | RGD:1310820 | 298069 | ||||||
Dog | collagen type XV alpha 1 chain | VGNC:39460 | 474778 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | collagen type XV alpha 1 chain | |||||
Macaque | collagen type XV alpha 1 chain | |||||
Mouse | ||||||
Rat | ||||||
Dog | collagen type XV alpha 1 chain | |||||
Publication Statistics
PubMed Score 26.88
PubMed score by year
PubTator Score 16.65
PubTator score by year
Related Publications
Text Mined References (41)
GeneRif Annotations (15)
Items per page:
0 of 0
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