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Tbio
COL15A1
Collagen alpha-1(XV) chain

Protein Summary
Description
Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle. Restin potently inhibits angiogenesis. This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375001
  • ENSP00000364140
  • ENSG00000204291
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.81
PubMedID
0.81
small molecule perturbation
0.65
cell line
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.88   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.88   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
COL3A1
Tbio
Novelty:  0.00197327
Score:  0.946
Data Source:  STRINGDB
COL1A2
Tbio
Novelty:  0.00048334
Score:  0.945
Data Source:  STRINGDB
COL6A3
Tbio
Novelty:  0.00805254
Score:  0.943
Data Source:  STRINGDB
COL1A1
Tbio
Novelty:  0.00063584
Score:  0.939
Data Source:  STRINGDB
COL5A1
Tbio
Novelty:  0.00506815
Score:  0.939
Data Source:  STRINGDB
COL5A2
Tbio
Novelty:  0.01352973
Score:  0.935
Data Source:  STRINGDB
COL16A1
Tbio
Novelty:  0.11147945
Score:  0.935
Data Source:  STRINGDB
COL4A1
Tbio
Novelty:  0.00358049
Score:  0.935
Data Source:  STRINGDB
COL14A1
Tbio
Novelty:  0.01760399
Score:  0.935
Data Source:  STRINGDB
COL6A2
Tbio
Novelty:  0.01275082
Score:  0.934
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen degradation
Reactome
Collagen formation
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen degradation
Collagen formation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
75.9
BMI-adjusted waist circumference
1
3
3
67.8
2
2
0
1.1
60.4
2
2
0
1.1
51.4
waist-hip ratio
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
75.9
BMI-adjusted waist circumference
3
67.8
0
1.1
60.4
0
1.1
51.4
waist-hip ratio
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collagen type XV alpha 1 chain
VGNC:10680
464611
Macaque
collagen type XV alpha 1 chain
715003
Mouse
MGI:88449
12819
Rat
RGD:1310820
298069
Dog
collagen type XV alpha 1 chain
VGNC:39460
474778
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collagen type XV alpha 1 chain
Macaque
collagen type XV alpha 1 chain
Mouse
Rat
Dog
collagen type XV alpha 1 chain
Publication Statistics
PubMed Score 26.88
PubMed score by year
PubTator Score 16.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title