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Tbio
RPL3
60S ribosomal protein L3

Protein Summary
Description
The L3 protein is a component of the large subunit of cytoplasmic ribosomes. Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216146
  • ENSP00000346001
  • ENSG00000100316

Symbol
  • L3
  • ASC-1
  • TARBP-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
0.99
hub protein
0.98
transcription factor binding site profile
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.86   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.86   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
1
1.2
81.4
2
2
0
1.2
81.4
4
2
3
1.1
68.8
3
3
0
1.4
63.7
esterified cholesterol measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.2
81.4
0
1.2
81.4
3
1.1
68.8
0
1.4
63.7
esterified cholesterol measurement
1
17.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
60S ribosomal protein L3-like
709201
Mouse
MGI:1351605
27367
Rat
RGD:735105
300079
Dog
ribosomal protein L3
474504
Horse
ribosomal protein L3
VGNC:22528
100070291
Species
Name
OMA
EggNOG
Inparanoid
Macaque
60S ribosomal protein L3-like
Mouse
Rat
Dog
ribosomal protein L3
Horse
ribosomal protein L3
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P39023-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (529)
1 – 10 of 529
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.990211499
p_ni:  0.009788501
Score:  0.812
Data Source:  BioPlex,STRINGDB
NPM1
Tbio
Novelty:  0.0005485
p_int:  0.982761458
p_ni:  0.017238542
Score:  0.746
Data Source:  BioPlex,STRINGDB
MAGEB10
Tdark
Novelty:  2.96156972
p_int:  0.972750344
p_ni:  0.027249656
Data Source:  BioPlex
H2AFY2
Tbio
Novelty:  0.09948698
p_int:  0.953916251
p_ni:  0.046083749
Data Source:  BioPlex
PRR11
Tbio
Novelty:  0.05077483
p_int:  0.931160942
p_ni:  0.068839058
Data Source:  BioPlex
NOP53
Tbio
Novelty:  0.00353077
p_int:  0.931087557
p_ni:  0.068912443
Score:  0.937
Data Source:  BioPlex,STRINGDB
EBNA1BP2
Tbio
Novelty:  0.02083466
p_int:  0.925680196
p_ni:  0.074319804
Score:  0.94
Data Source:  BioPlex,STRINGDB
RPL18A
Tbio
Novelty:  0.04612948
p_int:  0.922701662
p_ni:  0.077298338
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPL37A
Tbio
Novelty:  0.03475061
p_int:  0.915239123
p_ni:  0.084760877
Score:  0.999
Data Source:  BioPlex,STRINGDB
MAK16
Tdark
Novelty:  0.07717917
p_int:  0.906095603
p_ni:  0.093904397
Score:  0.738
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  172.86

PubMed score by year
PubTator Score  29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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