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Tbio
CDKN1A
Cyclin-dependent kinase inhibitor 1

Protein Summary
Description
May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244741
  • ENSP00000244741
  • ENSG00000124762
  • ENST00000373711
  • ENSP00000362815
  • ENST00000405375
  • ENSP00000384849
  • ENST00000448526
  • ENSP00000409259
  • ENST00000615513
  • ENSP00000482768

Symbol
  • CAP20
  • CDKN1
  • CIP1
  • MDA6
  • PIC1
  • SDI1
  • WAF1
  • P21
  • CIP1
  • SDI1
  • WAF1
  • CAP20
  • CDKN1
  • MDA-6
  • p21CIP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
hub protein
1
kinase
1
PubMedID
1


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3352.41   (req: < 5)
Gene RIFs: 1291   (req: <= 3)
Antibodies: 2233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3352.41   (req: >= 5)
Gene RIFs: 1291   (req: > 3)
Antibodies: 2233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
84.8
2
2
0
1.1
75.7
electrocardiography
1
1
16
60.5
pulse pressure measurement
1
1
1
60.3
heart failure
1
1
0
1.1
47.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
84.8
0
1.1
75.7
electrocardiography
16
60.5
pulse pressure measurement
1
60.3
heart failure
0
1.1
47.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase inhibitor 1A
VGNC:8159
104001067
Macaque
cyclin dependent kinase inhibitor 1A
719199
Mouse
MGI:104556
12575
Rat
RGD:69328
114851
Dog
cyclin dependent kinase inhibitor 1A
VGNC:39068
474890
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase inhibitor 1A
Macaque
cyclin dependent kinase inhibitor 1A
Mouse
Rat
Dog
cyclin dependent kinase inhibitor 1A
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P38936-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (155)
AKT phosphorylates targets in the cytosol (R-HSA-198323)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 52
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AKT phosphorylates targets in the cytosol
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Reactome
Cellular Senescence
Name
Explore in Pharos
Explore in Source
AKT phosphorylates targets in the cytosol
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Cellular Senescence
Gene Ontology Terms (61)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (463)
1 – 10 of 463
CCNE1
Tchem
Novelty: 0.00237201
p_int: 0.999999949
p_ni: 3e-9
p_wrong: 4.8e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CCNB3
Tbio
Novelty: 0.01885821
p_int: 0.999999946
p_ni: 5.4e-8
Score: 0.367
Data Source: BioPlex,STRINGDB
CCND2
Tbio
Novelty: 0.00157305
p_int: 0.999999524
p_ni: 3.33e-7
p_wrong: 1.44e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
CCND1
Tchem
Novelty: 0.0001186
p_int: 0.999998862
p_ni: 0.000001135
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CCNB1
Tchem
Novelty: 0.0005503
p_int: 0.999998484
p_ni: 0.000001516
Score: 0.993
Data Source: BioPlex,STRINGDB
CCNE2
Tbio
Novelty: 0.00795182
p_int: 0.999993563
p_ni: 0.000006427
p_wrong: 1e-8
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
CCNA2
Tchem
Novelty: 0.00049887
p_int: 0.999968465
p_ni: 0.000023617
p_wrong: 0.000007919
Score: 0.999
Data Source: BioPlex,STRINGDB
CCND3
Tchem
Novelty: 0.00223085
p_int: 0.999956785
p_ni: 8.64e-7
p_wrong: 0.000042351
Score: 0.999
Data Source: BioPlex,STRINGDB
CKS2
Tbio
Family: Enzyme
Novelty: 0.02482411
p_int: 0.999891004
p_ni: 0.000108706
p_wrong: 2.9e-7
Score: 0.73
Data Source: BioPlex,STRINGDB
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
p_int: 0.999755771
p_ni: 0.000244228
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  3352.41

PubMed score by year
PubTator Score  4394.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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