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Tbio
HSPA9
Stress-70 protein, mitochondrial

Protein Summary
Description
Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). May play a role in the control of cell proliferation and cellular aging (By similarity). This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297185
  • ENSP00000297185
  • ENSG00000113013
  • ENST00000649126
  • ENSP00000496940

Symbol
  • GRP75
  • HSPA9B
  • mt-HSP70
  • CSA
  • MOT
  • MOT2
  • SAAN
  • CRP40
  • EVPLS
  • GRP75
  • PBP74
  • GRP-75
  • HSPA9B
  • SIDBA4
  • MTHSP75
  • HEL-S-124m
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
kinase perturbation
1
protein complex
1
transcription factor perturbation
0.99


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 467.33   (req: < 5)
Gene RIFs: 84   (req: <= 3)
Antibodies: 675   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 467.33   (req: >= 5)
Gene RIFs: 84   (req: > 3)
Antibodies: 675   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (18)
1 – 5 of 18
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family A (Hsp70) member 9
VGNC:6936
462099
Macaque
heat shock protein family A (Hsp70) member 9
714506
Mouse
MGI:96245
15526
Rat
RGD:1311806
291671
Dog
heat shock protein family A (Hsp70) member 9
VGNC:51725
474697
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family A (Hsp70) member 9
Macaque
heat shock protein family A (Hsp70) member 9
Mouse
Rat
Dog
heat shock protein family A (Hsp70) member 9
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (30)
Cellular response to heat stress (R-HSA-3371556)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Cristae formation
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Cristae formation
Cytokine Signaling in Immune system
Gene Ontology Terms (27)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (471)
1 – 10 of 471
GRPEL1
Tbio
Novelty: 0.00185346
p_int: 0.99998938
p_ni: 0.00001062
Score: 0.999
Data Source: BioPlex,STRINGDB
DNAJC13
Tbio
Novelty: 0.03251995
p_int: 0.999641572
p_ni: 0.000358428
Score: 0.437
Data Source: BioPlex,STRINGDB
DNLZ
Tdark
Novelty: 0.10113346
p_int: 0.996957121
p_ni: 0.003042259
p_wrong: 6.2e-7
Score: 0.946
Data Source: BioPlex,STRINGDB
SLAIN1
Tdark
Novelty: 0.20438696
p_int: 0.996121677
p_ni: 0.002823326
p_wrong: 0.001054997
Score: 0.243
Data Source: BioPlex,STRINGDB
DENND2D
Tbio
Novelty: 0.16496649
p_int: 0.984764159
p_ni: 0.015235841
Score: 0.214
Data Source: BioPlex,STRINGDB
MAVS
Tbio
Novelty: 0.00241215
p_int: 0.965219909
p_ni: 0.034780091
Score: 0.227
Data Source: BioPlex,STRINGDB
NHSL2
Tdark
Novelty: 4.36275023
p_int: 0.918695559
p_ni: 0.081304441
Data Source: BioPlex
PRCC
Tbio
Novelty: 0.00836323
p_int: 0.883916951
p_ni: 0.116083049
Score: 0.177
Data Source: BioPlex,STRINGDB
KIAA1191
Tdark
Family: Enzyme
Novelty: 3.7888034
p_int: 0.881162137
p_ni: 0.118837863
Score: 0.214
Data Source: BioPlex,STRINGDB
HS3ST3B1
Tbio
Family: Enzyme
Novelty: 0.08796166
p_int: 0.873222434
p_ni: 0.126777566
Data Source: BioPlex
Publication Statistics
PubMed Score  467.33

PubMed score by year
PubTator Score  185.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer