Tchem HSPA9 Stress-70 protein, mitochondrial

Protein Summary

Description

Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). May play a role in the control of cell proliferation and cellular aging (By similarity). This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010]

Uniprot Accession IDs

• P38646
• B2RCM1
• P30036
• P31932
• Q1HB43
• Q53H23
• Q6GU03
• Q9BWB7
• Q9UC56

Gene Name

• HSPA9

Ensembl ID

• ENST00000297185
• ENSP00000297185
• ENSG00000113013
• ENST00000649126
• ENSP00000496940

Symbol

• GRP75
• HSPA9B
• mt-HSP70
• CSA
• MOT
• MOT2
• SAAN
• CRP40
• EVPLS
• GRP75
• PBP74
• GRP-75
• HSPA9B
• SIDBA4
• MTHSP75
• HEL-S-124m

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
interacting protein	1
kinase perturbation	1
protein complex	1
transcription factor perturbation	0.99

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 605.44   (req: < 5)

Gene RIFs: 114   (req: <= 3)

Antibodies: 675   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 605.44   (req: >= 5)

Gene RIFs: 114   (req: > 3)

Antibodies: 675   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0