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Tbio
ATP6V1A
V-type proton ATPase catalytic subunit A

Protein Classes
Protein Summary
Description
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in neurite development and synaptic connectivity (PubMed:29668857). This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273398
  • ENSP00000273398
  • ENSG00000114573

Symbol
  • ATP6A1
  • ATP6V1A1
  • VPP2
  • HO68
  • VA68
  • VPP2
  • Vma1
  • ARCL2D
  • ATP6A1
  • IECEE3
  • ATP6V1A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
molecular function
1
interacting protein
0.98
protein domain
0.97
transcription factor perturbation
0.97


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.8   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.8   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V1 subunit A
VGNC:53358
460590
Mouse
MGI:1201780
11964
Rat
RGD:1596464
685232
Dog
ATPase H+ transporting V1 subunit A
VGNC:38276
487981
Horse
ATPase H+ transporting V1 subunit A
VGNC:15675
100061223
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V1 subunit A
Mouse
Rat
Dog
ATPase H+ transporting V1 subunit A
Horse
ATPase H+ transporting V1 subunit A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P38606-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (21)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Insulin receptor recycling
Reactome
Ion channel transport
Reactome
Iron uptake and transport
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Insulin receptor recycling
Ion channel transport
Iron uptake and transport
Gene Ontology Terms (20)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (158)
1 – 10 of 158
ATP6V1B1
Tchem
Family: Enzyme
Novelty: 0.01122589
p_int: 0.999822074
p_ni: 0.000177926
Score: 0.999
Data Source: BioPlex,STRINGDB
ATP6V1C2
Tbio
Family: Enzyme
Novelty: 0.07583427
p_int: 0.999725722
p_ni: 0.000274278
Score: 0.999
Data Source: BioPlex,STRINGDB
ATP6V1D
Tbio
Family: Enzyme
Novelty: 0.02298626
p_int: 0.99918639
p_ni: 0.00081361
Score: 0.999
Data Source: BioPlex,STRINGDB
ATP6V1B2
Tchem
Family: Enzyme
Novelty: 0.01767911
Score: 0.999
Data Source: STRINGDB
ATP6V1H
Tbio
Family: Enzyme
Novelty: 0.04269105
Score: 0.999
Data Source: STRINGDB
ATP6V1E1
Tbio
Family: Enzyme
Novelty: 0.04832113
Score: 0.998
Data Source: STRINGDB
ATP6V0D1
Tbio
Family: Enzyme
Novelty: 0.05146108
Score: 0.997
Data Source: STRINGDB
ATP6V1F
Tbio
Family: Enzyme
Novelty: 0.07109314
Score: 0.997
Data Source: STRINGDB
ATP6V1C1
Tbio
Family: Enzyme
Novelty: 0.03660846
Score: 0.997
Data Source: STRINGDB
ATP6V1E2
Tbio
Family: Enzyme
Novelty: 0.10447007
Score: 0.996
Data Source: STRINGDB
Publication Statistics
PubMed Score  105.80

PubMed score by year
PubTator Score  12.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer