LIPA
Lysosomal acid lipase/cholesteryl ester hydrolase
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
metabolite | 1 | ||
transcription factor perturbation | 1 | ||
virus perturbation | 0.88 | ||
cell type or tissue | 0.71 | ||
kinase perturbation | 0.71 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | LDL clearance | ||||
Reactome | Plasma lipoprotein assembly, remodeling, and clearance | ||||
Reactome | Plasma lipoprotein clearance | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
LDL clearance | ||||
Plasma lipoprotein assembly, remodeling, and clearance | ||||
Plasma lipoprotein clearance | ||||
Transport of small molecules | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 4 | 4 | 4 | 95.1 | |||||
9 | 3 | 4 | 1.1 | 92.3 | |||||
3 | 3 | 0 | 1.1 | 88.7 | |||||
neutrophil count | 3 | 2 | 3 | 88.5 | |||||
myeloid white cell count | 1 | 1 | 1 | 75.7 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
C-reactive protein measurement | 4 | 95.1 | |||||
4 | 1.1 | 92.3 | |||||
0 | 1.1 | 88.7 | |||||
neutrophil count | 3 | 88.5 | |||||
myeloid white cell count | 1 | 75.7 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | lipase A, lysosomal acid type | VGNC:7847 | 466150 | |||||
Mouse | MGI:96789 | 16889 | ||||||
Rat | RGD:3008 | 25055 | ||||||
Dog | lipase A, lysosomal acid type | VGNC:42693 | 100856363 | |||||
Horse | lipase A, lysosomal acid type | VGNC:19685 | 100071626 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | lipase A, lysosomal acid type | |||||
Mouse | ||||||
Rat | ||||||
Dog | lipase A, lysosomal acid type | |||||
Horse | lipase A, lysosomal acid type | |||||
PMID | Year | Title |
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