Tbio IFNGR2 Interferon gamma receptor 2

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Type Ii Cytokine Receptor / Interferon Gamma Receptor 2

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Interferon Gamma Receptor 2

Protein / Defense/immunity Protein / Interferon Gamma Receptor 2

DTO Classes

Protein / Receptor / Cytokine Receptor / Type Ii Cytokine Receptor / Interferon Gamma Receptor 2

Protein Summary

Description

Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:8124716, PubMed:7673114,PubMed:7615558). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:8124716, PubMed:7673114, PubMed:15356148). Required for signal transduction in contrast to other receptor subunit responsible for ligand binding (PubMed:7673114). This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P38484
• Q9BTL5
• IFN-gamma receptor 2

Gene Name

• IFNGR2

Ensembl ID

• ENST00000290219
• ENSP00000290219
• ENSG00000159128
• ENST00000576463
• ENSP00000458487
• ENSG00000262795

Symbol

• IFNGT1
• AF-1
• IFGR2
• IMD28
• IFNGT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
kinase perturbation	0.93
transcription factor perturbation	0.91
transcription factor binding site profile	0.77
PubMedID	0.76

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.55   (req: < 5)

Gene RIFs: 47   (req: <= 3)

Antibodies: 383   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.55   (req: >= 5)

Gene RIFs: 47   (req: > 3)

Antibodies: 383   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (32)

Reactome (5)

KEGG (18)

PathwayCommons (5)

WikiPathways (4)

Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Interferon Signaling	280 targets	R-HSA-913531
Reactome	Interferon gamma signaling	172 targets	R-HSA-877300
Reactome	Regulation of IFNG signaling	14 targets	R-HSA-877312

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Immune System	2246 targets	R-HSA-168256
Interferon Signaling	280 targets	R-HSA-913531
Interferon gamma signaling	172 targets	R-HSA-877300
Regulation of IFNG signaling	14 targets	R-HSA-877312

Gene Ontology Terms (12)

Functions (1)

Components (6)

Processes (5)

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
interferon-gamma receptor activity	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (102)

Explore Interacting Targets

1 – 10 of 102

• See Interactions on String-DB

IFNGR1

Tbio

Novelty: 0.00552398

Score: 0.991

Data Source: Reactome,STRINGDB

JAK1

Tclin

Family: Kinase

Novelty: 0.00136831

Score: 0.979

Data Source: Reactome,STRINGDB

JAK2

Tclin

Family: Kinase

Novelty: 0.00028252

Score: 0.976

Data Source: Reactome,STRINGDB

IFNG

Tclin

Novelty: 0.00011491

Score: 0.968

Data Source: Reactome,STRINGDB

IFNAR2

Tclin

Novelty: 0.00573978

Score: 0.95

Data Source: STRINGDB

SOCS1

Tbio

Novelty: 0.0006161

Score: 0.935

Data Source: Reactome,STRINGDB

STAT1

Tchem

Family: TF

Novelty: 0.00041067

Score: 0.933

Data Source: Reactome,STRINGDB

SOCS3

Tbio

Novelty: 0.00082008

Score: 0.926

Data Source: Reactome,STRINGDB

PTPN11

Tchem

Family: Enzyme

Novelty: 0.00086268

Score: 0.912

Data Source: Reactome,STRINGDB

CAMK2D

Tchem

Family: Kinase

Novelty: 0.02987369

Score: 0.908

Data Source: Reactome,STRINGDB

Publication Statistics

PubMed Score  49.55

PubMed score by year

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PubTator Score  264.4

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MRPTLLWSLLLLLGVFAAAAAAPPDPLSQLPAPQHPKIRLYNAEQVLSWEPVALSNSTRPVVYQVQFKYT

1-70

DSKWFTADIMSIGVNCTQITATECDFTAASPSAGFPMDFNVTLRLRAELGALHSAWVTMPWFQHYRNVTV

70-140

GPPENIEVTPGEGSLIIRFSSPFDIADTSTAFFCYYVHYWEKGGIQQVKGPFRSNSISLDNLKPSRVYCL

140-210

QVQAQLLWNKSNIFRVGHLSNISCYETMADASTELQQVILISVGTFSLLSVLAGACFFLVLKYRGLIKYW

210-280

FHTPPSIPLQIEEYLKDPTQPILEALDKDSSPKDDVWDSVSIISFPEKEQEDVLQTL

280-337

MRPTLLWSLLLLLGVFAAAAAAPPDPLSQLPAPQHPKIRLYNAEQVLSWEPVALSNSTRPVVYQVQFKYTDSKWFTADIMSIGVNCTQITATECDFTAASPSAGFPMDFNVTLRLRAELGALHSAWVTMPWFQHYRNVTVGPPENIEVTPGEGSLIIRFSSPFDIADTSTAFFCYYVHYWEKGGIQQVKGPFRSNSISLDNLKPSRVYCLQVQAQLLWNKSNIFRVGHLSNISCYETMADASTELQQVILISVGTFSLLSVLAGACFFLVLKYRGLIKYWFHTPPSIPLQIEEYLKDPTQPILEALDKDSSPKDDVWDSVSIISFPEKEQEDVLQTL

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Uniprot Keyword

3D-structure
Cell membrane
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Disease mutation
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Golgi apparatus