IFNGR2
Interferon gamma receptor 2
Protein Summary
Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:8124716, PubMed:7673114,PubMed:7615558). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:8124716, PubMed:7673114, PubMed:15356148). Required for signal transduction in contrast to other receptor subunit responsible for ligand binding (PubMed:7673114). This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]
- ENST00000290219
- ENSP00000290219
- ENSG00000159128
- ENST00000576463
- ENSP00000458487
- ENSG00000262795
- IFNGT1
- AF-1
- IFGR2
- IMD28
- IFNGT1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.93 | ||
kinase perturbation | 0.93 | ||
transcription factor perturbation | 0.91 | ||
transcription factor binding site profile | 0.77 | ||
PubMedID | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 75.16 (req: < 5)
Gene RIFs: 47 (req: <= 3)
Antibodies: 383 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 75.16 (req: >= 5)
Gene RIFs: 47 (req: > 3)
Antibodies: 383 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (102)
Nearest Tclin Targets (9)
Upstream (5)
Downstream (4)
1 – 5 of 5
IL12B
IL12A
IL23A
Pathways (32)
Reactome (5)
KEGG (18)
PathwayCommons (5)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | Interferon Signaling | ||||
Reactome | Interferon gamma signaling | ||||
Reactome | Regulation of IFNG signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Interferon Signaling | ||||
Interferon gamma signaling | ||||
Regulation of IFNG signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (1)
Components (6)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
blood protein measurement | 1 | 2 | 2 | 84.6 | |||||
2 | 1 | 0 | 1.1 | 83.6 | |||||
1 | 2 | 0 | 1.1 | 58.2 | |||||
multiple sclerosis | 1 | 1 | 0 | 1.1 | 45.5 | ||||
1 | 1 | 0 | 1.1 | 33.5 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
blood protein measurement | 2 | 84.6 | |||||
0 | 1.1 | 83.6 | |||||
0 | 1.1 | 58.2 | |||||
multiple sclerosis | 0 | 1.1 | 45.5 | ||||
0 | 1.1 | 33.5 | |||||
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IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | interferon gamma receptor 2 | VGNC:14663 | 470077 | |||||
Macaque | interferon gamma receptor 2 | 699489 | ||||||
Mouse | MGI:107654 | 15980 | ||||||
Rat | RGD:1307532 | 360697 | ||||||
Dog | interferon gamma receptor 2 | 487739 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | interferon gamma receptor 2 | |||||
Macaque | interferon gamma receptor 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | interferon gamma receptor 2 | |||||
Publication Statistics
PubMed Score 75.16
PubMed score by year
PubTator Score 264.40
PubTator score by year
Related Publications
Text Mined References (94)
GeneRif Annotations (47)
Items per page:
0 of 0
PMID | Year | Title |
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