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Tchem
BRCA1
Breast cancer type 1 susceptibility protein

Protein Summary
Description
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by bindi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000352993
  • ENSP00000312236
  • ENSG00000012048
  • ENST00000357654
  • ENSP00000350283
  • ENST00000461221
  • ENSP00000418548
  • ENST00000461798
  • ENSP00000417988
  • ENST00000468300
  • ENSP00000417148
  • ENST00000471181
  • ENSP00000418960
  • ENST00000491747
  • ENSP00000420705
  • ENST00000493795
  • ENSP00000418775

Symbol
  • RNF53
  • IRIS
  • PSCP
  • BRCAI
  • BRCC1
  • FANCS
  • PNCA4
  • RNF53
  • BROVCA1
  • PPP1R53
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
co-expressed gene
0.99
kinase
0.99
molecular function
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11366.24   (req: < 5)
Gene RIFs: 2045   (req: <= 3)
Antibodies: 2084   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11366.24   (req: >= 5)
Gene RIFs: 2045   (req: > 3)
Antibodies: 2084   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 69
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0