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Tchem
ETFB
Electron transfer flavoprotein subunit beta

Protein Summary
Description
Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:25416781, PubMed:15159392, PubMed:15975918). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:7912128). ETFB binds an AMP molecule that probably has a purely structural role (PubMed:8962055, PubMed:15159392, PubMed:15975918). This gene encodes electron-transfer-flavoprotein, beta polypeptide, which shuttles electrons between primary flavoprotein dehydrogenases involved in mitochondrial fatty acid and amino acid catabolism and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. The gene deficiencies have been implicated in type II glutaricaciduria. Alternatively spliced transcript variants hav ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309244
  • ENSP00000311930
  • ENSG00000105379
  • ENST00000354232
  • ENSP00000346173

Symbol
  • MADD
  • FP585
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
disease perturbation
0.93
transcription factor binding site profile
0.88
transcription factor perturbation
0.88
transcription factor
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.37   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.37   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (125)
ETFRF1
Tdark
Novelty:  1.28847105
p_int:  0.999999994
p_ni:  6e-9
Score:  0.552
Data Source:  BioPlex,STRINGDB
ETFA
Tbio
Novelty:  0.00193499
p_int:  0.999999668
p_ni:  3.32e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
GMCL1
Tbio
Novelty:  0.1543762
p_int:  0.998516935
p_ni:  0.001434878
p_wrong:  0.000048186
Data Source:  BioPlex
AKAP11
Tbio
Family:  Enzyme
Novelty:  0.0685826
p_int:  0.958535442
p_ni:  0.041464558
Score:  0.392
Data Source:  BioPlex,STRINGDB
PRKACB
Tchem
Family:  Kinase
Novelty:  0.01962222
p_int:  0.955474584
p_ni:  0.044525416
Score:  0.556
Data Source:  BioPlex,STRINGDB
NDUFAB1
Tclin
Novelty:  0.00190242
p_int:  0.878735995
p_ni:  0.121264005
Score:  0.839
Data Source:  BioPlex,STRINGDB
KNL1
Tbio
Novelty:  0.01084826
p_int:  0.865419639
p_ni:  0.134580361
Score:  0.524
Data Source:  BioPlex,STRINGDB
DSN1
Tbio
Novelty:  0.05336903
p_int:  0.856408756
p_ni:  0.143492224
p_wrong:  0.00009902
Score:  0.217
Data Source:  BioPlex,STRINGDB
PLCH1
Tbio
Family:  Enzyme
Novelty:  0.11128204
p_int:  0.817349092
p_ni:  0.001671647
p_wrong:  0.180979261
Score:  0.232
Data Source:  BioPlex,STRINGDB
PRKAR1B
Tbio
Family:  Enzyme
Novelty:  0.05355517
p_int:  0.779945011
p_ni:  0.220054979
p_wrong:  1e-8
Score:  0.437
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Protein methylation
Reactome
Respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of proteins
Post-translational protein modification
Protein methylation
Respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
61.8
neutrophil count
2
2
2
58.2
HbA1c measurement
1
1
1
44.2
lymphocyte percentage of leukocytes
1
1
1
33.1
body height
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
61.8
neutrophil count
2
58.2
HbA1c measurement
1
44.2
lymphocyte percentage of leukocytes
1
33.1
body height
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
electron transfer flavoprotein beta subunit
456243
Macaque
electron transfer flavoprotein beta subunit
719606
Mouse
MGI:106098
110826
Rat
RGD:1303312
292845
Dog
electron transfer flavoprotein subunit beta
VGNC:53709
476400
Species
Name
OMA
EggNOG
Inparanoid
Chimp
electron transfer flavoprotein beta subunit
Macaque
electron transfer flavoprotein beta subunit
Mouse
Rat
Dog
electron transfer flavoprotein subunit beta
Publication Statistics
PubMed Score 45.37
PubMed score by year
PubTator Score 25.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title