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Tbio
ETFB
Electron transfer flavoprotein subunit beta

Protein Summary
Description
Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:25416781, PubMed:15159392, PubMed:15975918). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:7912128). ETFB binds an AMP molecule that probably has a purely structural role (PubMed:8962055, PubMed:15159392, PubMed:15975918). This gene encodes electron-transfer-flavoprotein, beta polypeptide, which shuttles electrons between primary flavoprotein dehydrogenases involved in mitochondrial fatty acid and amino acid catabolism and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. The gene deficiencies have been implicated in type II glutaricaciduria. Alternatively spliced transcript variants hav ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309244
  • ENSP00000311930
  • ENSG00000105379
  • ENST00000354232
  • ENSP00000346173

Symbol
  • MADD
  • FP585
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
disease perturbation
0.93
transcription factor binding site profile
0.88
transcription factor perturbation
0.88
transcription factor
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.01   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.01   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Protein methylation
Reactome
Respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of proteins
Post-translational protein modification
Protein methylation
Respiratory electron transport
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (125)
1 – 10 of 125
ETFRF1
Tdark
Novelty: 2
p_int: 0.999999994
p_ni: 6e-9
Score: 0.552
Data Source: BioPlex,STRINGDB
ETFA
Tbio
Novelty: 0.00300551
p_int: 0.999999668
p_ni: 3.32e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
GMCL1
Tbio
Novelty: 0.1349742
p_int: 0.998516935
p_ni: 0.001434878
p_wrong: 0.000048186
Data Source: BioPlex
AKAP11
Tbio
Family: Enzyme
Novelty: 0.09306887
p_int: 0.958535442
p_ni: 0.041464558
Score: 0.392
Data Source: BioPlex,STRINGDB
PRKACB
Tchem
Family: Kinase
Novelty: 0.03136062
p_int: 0.955474584
p_ni: 0.044525416
Score: 0.556
Data Source: BioPlex,STRINGDB
NDUFAB1
Tclin
Novelty: 0.00207106
p_int: 0.878735995
p_ni: 0.121264005
Score: 0.839
Data Source: BioPlex,STRINGDB
KNL1
Tbio
Novelty: 0.00616496
p_int: 0.865419639
p_ni: 0.134580361
Score: 0.524
Data Source: BioPlex,STRINGDB
DSN1
Tbio
Novelty: 0.08344924
p_int: 0.856408756
p_ni: 0.143492224
p_wrong: 0.00009902
Score: 0.217
Data Source: BioPlex,STRINGDB
PLCH1
Tbio
Family: Enzyme
Novelty: 0.20668236
p_int: 0.817349092
p_ni: 0.001671647
p_wrong: 0.180979261
Score: 0.232
Data Source: BioPlex,STRINGDB
PRKAR1B
Tbio
Family: Enzyme
Novelty: 0.01102811
p_int: 0.779945011
p_ni: 0.220054979
p_wrong: 1e-8
Score: 0.437
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  28.01

PubMed score by year
PubTator Score  25.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer