Tchem ETFB Electron transfer flavoprotein subunit beta

Protein Summary

Description

Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:25416781, PubMed:15159392, PubMed:15975918). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:7912128). ETFB binds an AMP molecule that probably has a purely structural role (PubMed:8962055, PubMed:15159392, PubMed:15975918). This gene encodes electron-transfer-flavoprotein, beta polypeptide, which shuttles electrons between primary flavoprotein dehydrogenases involved in mitochondrial fatty acid and amino acid catabolism and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. The gene deficiencies have been implicated in type II glutaricaciduria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P38117
• A8K766
• B3KNY2
• Q6IBH7
• Q71RF6
• Q9Y3S7
• Beta-ETF

Gene Name

• ETFB

Ensembl ID

• ENST00000309244
• ENSP00000311930
• ENSG00000105379
• ENST00000354232
• ENSP00000346173

Symbol

• MADD
• FP585

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
disease perturbation	0.93
transcription factor binding site profile	0.88
transcription factor perturbation	0.88
transcription factor	0.78

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Hydroxylase / Electron Transfer Flavoprotein Subunit Beta

DTO Classes

Protein / Enzyme / Oxidoreductase / Hydroxylase / Electron Transfer Flavoprotein Subunit Beta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.45   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 224   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.45   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0