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Tchem
SNCA
Alpha-synuclein

Protein Summary
Description
May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336904
  • ENSP00000338345
  • ENSG00000145335
  • ENST00000345009
  • ENSP00000343683
  • ENST00000394986
  • ENSP00000378437
  • ENST00000394989
  • ENSP00000378440
  • ENST00000394991
  • ENSP00000378442
  • ENST00000420646
  • ENSP00000396241
  • ENST00000505199
  • ENSP00000421485
  • ENST00000506244
  • ENSP00000422238
  • ENST00000508895
  • ENSP00000426955
  • ENST00000618500
  • ENSP00000484044

Symbol
  • NACP
  • PARK1
  • PD1
  • NACP
  • PARK1
  • PARK4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
kinase
1
molecular function
1
biological term
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10610.64   (req: < 5)
Gene RIFs: 1403   (req: <= 3)
Antibodies: 2667   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10610.64   (req: >= 5)
Gene RIFs: 1403   (req: > 3)
Antibodies: 2667   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 99
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 187
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (305)
MAN2C1
Tbio
Family:  Enzyme
Novelty:  0.01159051
p_int:  0.999995048
p_ni:  0.000004908
p_wrong:  4.4e-8
Score:  0.354
Data Source:  BioPlex,STRINGDB
TMPRSS12
Tbio
Family:  Enzyme
Novelty:  0.38051198
p_int:  0.997573342
p_ni:  0.002426658
Score:  0.208
Data Source:  BioPlex,STRINGDB
HK1
Tchem
Family:  Kinase
Novelty:  0.00195554
p_int:  0.992731345
p_ni:  0.007268655
Score:  0.254
Data Source:  BioPlex,STRINGDB
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.945120326
p_ni:  0.054879649
p_wrong:  2.5e-8
Data Source:  BioPlex
HCLS1
Tbio
Novelty:  0.08304056
p_int:  0.915728689
p_ni:  0.006128783
p_wrong:  0.078142528
Score:  0.269
Data Source:  BioPlex,STRINGDB
SERPINB13
Tbio
Novelty:  0.01753451
p_int:  0.882892549
p_ni:  0.117106916
p_wrong:  5.35e-7
Score:  0.165
Data Source:  BioPlex,STRINGDB
SNCAIP
Tbio
Novelty:  0.01355161
Score:  0.996
Data Source:  Reactome,STRINGDB
PRKN
Tbio
Family:  Enzyme
Novelty:  0.00079898
Score:  0.992
Data Source:  STRINGDB
PARK7
Tbio
Family:  Enzyme
Novelty:  0.00104651
Score:  0.99
Data Source:  STRINGDB
APP
Tclin
Novelty:  0.00008964
Score:  0.985
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (128)
Find Similar Targets
Items per page:
10
1 – 10 of 24
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Parkinson disease
18
8
3
1.3
99.8
blood protein measurement
2
2
2
83.9
1
1
0
1.4
79.2
age at onset
1
1
1
78.8
lymphocyte count
3
1
3
67.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Parkinson disease
3
1.3
99.8
blood protein measurement
2
83.9
0
1.4
79.2
age at onset
1
78.8
lymphocyte count
3
67.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
synuclein alpha
706985
Mouse
MGI:1277151
20617
Rat
RGD:3729
29219
Dog
synuclein alpha
VGNC:46596
478478
Horse
synuclein alpha
VGNC:23382
100053270
Species
Name
OMA
EggNOG
Inparanoid
Macaque
synuclein alpha
Mouse
Rat
Dog
synuclein alpha
Horse
synuclein alpha
Publication Statistics
PubMed Score 10610.64
PubMed score by year
PubTator Score 4467.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title