You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TALDO1
Transaldolase

Protein Summary
Description
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319006
  • ENSP00000321259
  • ENSG00000177156

Symbol
  • TAL
  • TALDO
  • TALDOR
  • TAL
  • TALH
  • TAL-H
  • TALDOR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
virus perturbation
0.99
kinase perturbation
0.81
transcription factor binding site profile
0.77
transcription factor perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 484.09   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 484.09   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
5
6
91.5
mean platelet volume
2
2
2
89.4
intraocular pressure measurement
2
3
3
89
waist-hip ratio
4
6
9
86.9
Keratoconus
2
2
1
6.6
82.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
6
91.5
mean platelet volume
2
89.4
intraocular pressure measurement
3
89
waist-hip ratio
9
86.9
Keratoconus
1
6.6
82.1
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transaldolase 1
VGNC:991
450933
Mouse
MGI:1274789
21351
Rat
RGD:620674
83688
Dog
transaldolase
475937
Horse
transaldolase 1
VGNC:23863
100055991
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transaldolase 1
Mouse
Rat
Dog
transaldolase
Horse
transaldolase 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P37837-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (37)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Reactome
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Protein-Protein Interactions (221)
1 – 10 of 221
DENR
Tbio
Novelty:  0.00653432
p_int:  0.954074854
p_ni:  0.045925146
Score:  0.172
Data Source:  BioPlex,STRINGDB
WDR45
Tbio
Novelty:  0.0148072
p_int:  0.951364457
p_ni:  0.048265923
p_wrong:  0.00036962
Score:  0.719
Data Source:  BioPlex,STRINGDB
CFDP1
Tbio
Novelty:  0.02175158
p_int:  0.943149301
p_ni:  0.056721788
p_wrong:  0.00012891
Score:  0.309
Data Source:  BioPlex,STRINGDB
PDE6D
Tclin
Family:  Enzyme
Novelty:  0.02276328
p_int:  0.88931388
p_ni:  0.110686089
p_wrong:  3.1e-8
Score:  0.555
Data Source:  BioPlex,STRINGDB
PMF1
Tbio
Novelty:  0.05319446
p_int:  0.865129225
p_ni:  0.134870742
p_wrong:  3.2e-8
Data Source:  BioPlex
SPC24
Tbio
Novelty:  0.03166479
p_int:  0.778950902
p_ni:  0.221049098
Score:  0.527
Data Source:  BioPlex,STRINGDB
MRC2
Tbio
Novelty:  0.01100289
p_int:  0.772932343
p_ni:  0.227067657
Score:  0.189
Data Source:  BioPlex,STRINGDB
ATG2B
Tbio
Novelty:  0.04963717
p_int:  0.762895117
p_ni:  0.237104682
p_wrong:  2.01e-7
Score:  0.67
Data Source:  BioPlex,STRINGDB
TKT
Tchem
Family:  Enzyme
Novelty:  0.00333936
Score:  0.999
Data Source:  STRINGDB
TKTL2
Tbio
Family:  Enzyme
Novelty:  0.0915871
Score:  0.994
Data Source:  STRINGDB
Publication Statistics
PubMed Score  484.09

PubMed score by year
PubTator Score  340.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: