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Tbio
TAGLN2
Transgelin-2

Protein Summary
Description
The protein encoded by this gene is similar to the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The specific function of this protein has not yet been determined, although it is thought to be a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320307
  • ENSP00000357075
  • ENSG00000158710
  • ENST00000368096
  • ENSP00000357076
  • ENST00000368097
  • ENSP00000357077

Symbol
  • KIAA0120
  • HA1756
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
PubMedID
0.94
transcription factor binding site profile
0.94
transcription factor perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.92   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.92   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
1
3
83.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
83.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transgelin 2
VGNC:1661
469546
Macaque
transgelin 2
719527
Mouse
MGI:1312985
21346
Rat
RGD:1310840
304983
Dog
transgelin 2
VGNC:47094
610210
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transgelin 2
Macaque
transgelin 2
Mouse
Rat
Dog
transgelin 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P37802-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (83)
1 – 10 of 83
TAGLN3
Tbio
Novelty: 0.01781784
p_int: 0.999999989
p_wrong: 1.1e-8
Score: 0.829
Data Source: BioPlex,STRINGDB
PPIA
Tclin
Family: Enzyme
Novelty: 0.00083881
Score: 0.837
Data Source: STRINGDB
SNRPF
Tdark
Novelty: 0.17624854
Score: 0.775
Data Source: STRINGDB
FABP5
Tchem
Novelty: 0.00570755
Score: 0.74
Data Source: STRINGDB
CFL1
Tbio
Novelty: 0.00071544
Score: 0.69
Data Source: STRINGDB
ACTB
Tbio
Novelty: 0.00006048
Score: 0.669
Data Source: STRINGDB
FCGR2B
Tbio
Novelty: 0.00098166
Score: 0.641
Data Source: STRINGDB
PLS3
Tbio
Novelty: 0.00650492
Score: 0.624
Data Source: STRINGDB
COTL1
Tbio
Novelty: 0.03402683
Score: 0.623
Data Source: STRINGDB
SCX
Tbio
Family: TF
Novelty: 0.01222743
Score: 0.586
Data Source: STRINGDB
Publication Statistics
PubMed Score  60.92

PubMed score by year
PubTator Score  34.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer