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Tclin
AVPR1A
Vasopressin V1a receptor

Protein Summary
Description
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment. The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299178
  • ENSP00000299178
  • ENSG00000166148

Symbol
  • AVPR1
  • V1aR
  • AVPR1
  • AVPR V1a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
1
biological process
0.99
molecular function
0.81
phenotype
0.77
gene perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 343.47   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 343.47   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 540
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 9
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (194)
1 – 10 of 194
AVP
Tbio
Novelty:  0.00016475
Score:  0.994
Data Source:  Reactome,STRINGDB
OXT
Tbio
Novelty:  0.00005116
Score:  0.981
Data Source:  STRINGDB
GRM5
Tchem
Family:  GPCR
Novelty:  0.00062552
Score:  0.961
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.961
Data Source:  STRINGDB
EDN3
Tbio
Novelty:  0.00116752
Score:  0.959
Data Source:  STRINGDB
ADRA1D
Tclin
Family:  GPCR
Novelty:  0.00203304
Score:  0.955
Data Source:  STRINGDB
GRK5
Tchem
Family:  Kinase
Novelty:  0.01108012
Score:  0.944
Data Source:  STRINGDB
EDN2
Tbio
Novelty:  0.00203492
Score:  0.941
Data Source:  STRINGDB
NTS
Tbio
Novelty:  0.00033201
Score:  0.934
Data Source:  STRINGDB
GRM1
Tchem
Family:  GPCR
Novelty:  0.00099764
Score:  0.931
Data Source:  STRINGDB
Pathways (18)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
G alpha (q) signalling events
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)
Disease
Disorders of transmembrane transporters
G alpha (q) signalling events
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
4
2
1
82.2
IGF-1 measurement
1
1
1
10.6
C-reactive protein measurement
1
1
1
2.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1
82.2
IGF-1 measurement
1
10.6
C-reactive protein measurement
1
2.7
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
arginine vasopressin receptor 1A
717041
Mouse
MGI:1859216
54140
Rat
RGD:2185
25107
Dog
arginine vasopressin receptor 1A
VGNC:38318
481142
Horse
arginine vasopressin receptor 1A
VGNC:15710
100056176
Species
Name
OMA
EggNOG
Inparanoid
Macaque
arginine vasopressin receptor 1A
Mouse
Rat
Dog
arginine vasopressin receptor 1A
Horse
arginine vasopressin receptor 1A
Publication Statistics
PubMed Score 343.47
PubMed score by year
PubTator Score 183.95
PubTator score by year
Patents
Patents by year