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Tbio
ZEB1
Zinc finger E-box-binding homeobox 1

Protein Summary
Description
Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been descr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320985
  • ENSP00000319248
  • ENSG00000148516
  • ENST00000361642
  • ENSP00000354487
  • ENST00000446923
  • ENSP00000391612
  • ENST00000542815
  • ENSP00000444891
  • ENST00000560721
  • ENSP00000452787

Symbol
  • AREB6
  • TCF8
  • BZP
  • TCF8
  • AREB6
  • FECD6
  • NIL2A
  • PPCD3
  • ZFHEP
  • ZFHX1A
  • DELTAEF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
biological process
0.97
biological term
0.95
microRNA
0.91
molecular function
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1540.65   (req: < 5)
Gene RIFs: 578   (req: <= 3)
Antibodies: 633   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1540.65   (req: >= 5)
Gene RIFs: 578   (req: > 3)
Antibodies: 633   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0