Pharos: Illuminating the Druggable Genome

Tchem

Protein Summary

Description

This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

Gene Name

FDFT1

Ensembl ID

ENST00000220584
ENSP00000220584
ENSG00000079459
ENST00000443614
ENSP00000390367
ENST00000525777
ENSP00000436069
ENST00000528643
ENSP00000431649
ENST00000528812
ENSP00000431749
ENST00000530664
ENSP00000432331
ENST00000538689
ENSP00000444248
ENST00000615631
ENSP00000481481
ENST00000618539
ENSP00000480828
ENST00000622850
ENSP00000484122
ENST00000623368
ENSP00000485229

Symbol

SS
SQS
DGPT
ERG9
SQSD

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	1

transcription factor perturbation	1

kinase perturbation	0.99

disease perturbation	0.97

interacting protein	0.95

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 420.47 (req: < 5)

View Publications

Gene RIFs: 21 (req: <= 3)

View Gene RIFs

Antibodies: 401 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 420.47 (req: >= 5)

Gene RIFs: 21 (req: > 3)

Antibodies: 401 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 208

Explore Active Ligands

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Explore Approved Drugs

Approved Drugs (1)

1 – 1 of 1

ibandronic acid

Active Ligands (208)

1 – 10 of 208

CHEMBL280978

CHEMBL86513,CHEMBL78510

Protein Data Bank (26)

1 – 5 of 26

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (57)

Reactome (8)

KEGG (2)

PathwayCommons (7)

UniProt (1)

WikiPathways (39)

Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of gene expression by SREBF (SREBP)	42 targets	R-HSA-2426168

Reactome	Cholesterol biosynthesis	25 targets	R-HSA-191273

Reactome	Metabolism	2112 targets	R-HSA-1430728

Reactome	Metabolism of lipids	740 targets	R-HSA-556833

Reactome	Metabolism of steroids	151 targets	R-HSA-8957322

Name	Explore in Pharos	Explore in Source
Activation of gene expression by SREBF (SREBP)	42 targets	R-HSA-2426168

Cholesterol biosynthesis	25 targets	R-HSA-191273

Metabolism	2112 targets	R-HSA-1430728

Metabolism of lipids	740 targets	R-HSA-556833

Metabolism of steroids	151 targets	R-HSA-8957322

Gene Ontology Terms (12)

Functions (2)

Components (3)

Processes (7)

Items per page:

1 – 2 of 2

GO Term	Evidence	Assigned by
farnesyl-diphosphate farnesyltransferase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

squalene synthase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (173)

1 – 10 of 173

See Interactions on String-DB

USP32

Tbio

Family: Enzyme

Novelty: 0.06653479

p_int: 0.999999775

p_ni: 2.25e-7

Score: 0.239

Data Source: BioPlex,STRINGDB

UNC93B1

Tbio

Novelty: 0.01966959

p_int: 0.999726218

p_ni: 0.000273772

p_wrong: 9e-9

Score: 0.309

Data Source: BioPlex,STRINGDB

CNNM1

Tdark

Novelty: 0.16670044

p_int: 0.999022393

p_ni: 0.00097411

p_wrong: 0.000003497

Score: 0.174

Data Source: BioPlex,STRINGDB

P2RX1

Tchem

Family: IC

Novelty: 0.00376724

p_int: 0.99736686

p_ni: 0.00263314

Score: 0.189

Data Source: BioPlex,STRINGDB

ADGRE5

Tbio

Family: GPCR

Novelty: 0.01324684

p_int: 0.891277721

p_ni: 0.108722279

Data Source: BioPlex

POMT2

Tbio

Family: Enzyme

Novelty: 0.03313606

p_int: 0.777360097

p_ni: 0.222639056

p_wrong: 8.47e-7

Score: 0.205

Data Source: BioPlex,STRINGDB

SQLE

Tchem

Family: Enzyme

Novelty: 0.01030355

Score: 0.997

Data Source: STRINGDB

FDPS

Tclin

Family: Enzyme

Novelty: 0.00202381

Score: 0.997

Data Source: STRINGDB

GGPS1

Tchem

Family: Enzyme

Novelty: 0.00446019

Score: 0.995

Data Source: STRINGDB

LSS

Tchem

Family: Enzyme

Novelty: 0.00164545

Score: 0.992

Data Source: STRINGDB

Publication Statistics

PubMed Score 420.47

PubMed score by year

PubTator Score 171.73

PubTator score by year

Amino Acid Sequence

Residue Counts

Sequence

MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVC

1-70

IFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQ

70-140

TVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLF

140-210

LQKTNIIRDYLEDQQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRL

210-280

RNQSVFNFCAIPQVMAIATLAACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIP

280-350

DSDPSSSKTRQIISTIRTQNLPNCQLISRSHYSPIYLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH

350-417

MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTRQIISTIRTQNLPNCQLISRSHYSPIYLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH

Find similar targets by:

Uniprot Keyword


3D-structure

Alternative splicing

Cholesterol biosynthesis

Cholesterol metabolism

Complete proteome

Endoplasmic reticulum

Isoprene biosynthesis

Lipid biosynthesis

Lipid metabolism

Magnesium