Protein Summary
This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]
- ENST00000220584
- ENSP00000220584
- ENSG00000079459
- ENST00000443614
- ENSP00000390367
- ENST00000525777
- ENSP00000436069
- ENST00000528643
- ENSP00000431649
- ENST00000528812
- ENSP00000431749
- ENST00000530664
- ENSP00000432331
- ENST00000538689
- ENSP00000444248
- ENST00000615631
- ENSP00000481481
- ENST00000618539
- ENSP00000480828
- ENST00000622850
- ENSP00000484122
- ENST00000623368
- ENSP00000485229
- SS
- SQS
- DGPT
- ERG9
- SQSD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
ligand (chemical) | 1 | ||
transcription factor perturbation | 1 | ||
kinase perturbation | 0.99 | ||
disease perturbation | 0.97 | ||
interacting protein | 0.95 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 474.52 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 401 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 474.52 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 401 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 208
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (208)
Protein-Protein Interactions (173)
USP32
Family: Enzyme
Novelty: 0.08043957
p_int: 0.999999775
p_ni: 2.25e-7
Score: 0.239
Data Source: BioPlex,STRINGDB
UNC93B1
Novelty: 0.01288921
p_int: 0.999726218
p_ni: 0.000273772
p_wrong: 9e-9
Score: 0.309
Data Source: BioPlex,STRINGDB
CNNM1
Novelty: 0.11053515
p_int: 0.999022393
p_ni: 0.00097411
p_wrong: 0.000003497
Score: 0.174
Data Source: BioPlex,STRINGDB
P2RX1
Family: IC
Novelty: 0.00286826
p_int: 0.99736686
p_ni: 0.00263314
Score: 0.189
Data Source: BioPlex,STRINGDB
ADGRE5
Family: GPCR
Novelty: 0.01137558
p_int: 0.891277721
p_ni: 0.108722279
Data Source: BioPlex
POMT2
Family: Enzyme
Novelty: 0.0251595
p_int: 0.777360097
p_ni: 0.222639056
p_wrong: 8.47e-7
Score: 0.205
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (57)
Reactome (8)
KEGG (2)
PathwayCommons (7)
UniProt (1)
WikiPathways (39)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of gene expression by SREBF (SREBP) | ||||
Reactome | Cholesterol biosynthesis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Metabolism of steroids | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of gene expression by SREBF (SREBP) | ||||
Cholesterol biosynthesis | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Metabolism of steroids | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (2)
Components (3)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (33)
Items per page:
1 – 5 of 33
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 3 | 5 | 5 | 93 | |||||
triglyceride measurement | 5 | 5 | 6 | 92.2 | |||||
reticulocyte count | 2 | 2 | 2 | 84.7 | |||||
BMI-adjusted waist circumference | 2 | 15 | 17 | 83.1 | |||||
reticulocyte measurement | 2 | 2 | 2 | 82.7 | |||||
Items per page:
1 – 5 of 33
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 5 | 93 | |||||
triglyceride measurement | 6 | 92.2 | |||||
reticulocyte count | 2 | 84.7 | |||||
BMI-adjusted waist circumference | 17 | 83.1 | |||||
reticulocyte measurement | 2 | 82.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | farnesyl-diphosphate farnesyltransferase 1 | VGNC:3014 | 740684 | |||||
Macaque | farnesyl-diphosphate farnesyltransferase 1 | 696396 | ||||||
Mouse | MGI:102706 | 14137 | ||||||
Rat | RGD:61834 | 29580 | ||||||
Dog | farnesyl-diphosphate farnesyltransferase 1 | VGNC:40811 | 477362 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | farnesyl-diphosphate farnesyltransferase 1 | |||||
Macaque | farnesyl-diphosphate farnesyltransferase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | farnesyl-diphosphate farnesyltransferase 1 | |||||
Publication Statistics
PubMed Score 474.52
PubMed score by year
PubTator Score 171.73
PubTator score by year
Related Publications
Text Mined References (44)
GeneRif Annotations (21)
Items per page:
0 of 0
PMID | Year | Title |
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