Protein Summary
This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]
- ENST00000220584
- ENSP00000220584
- ENSG00000079459
- ENST00000443614
- ENSP00000390367
- ENST00000525777
- ENSP00000436069
- ENST00000528643
- ENSP00000431649
- ENST00000528812
- ENSP00000431749
- ENST00000530664
- ENSP00000432331
- ENST00000538689
- ENSP00000444248
- ENST00000615631
- ENSP00000481481
- ENST00000618539
- ENSP00000480828
- ENST00000622850
- ENSP00000484122
- ENST00000623368
- ENSP00000485229
- SS
- SQS
- DGPT
- ERG9
- SQSD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
ligand (chemical) | 1 | ||
transcription factor perturbation | 1 | ||
kinase perturbation | 0.99 | ||
disease perturbation | 0.97 | ||
interacting protein | 0.95 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 634.06 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 401 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 634.06 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 401 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 208
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1