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Tbio
HPCAL1
Hippocalcin-like protein 1

Protein Summary
Description
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. It is highly similar to human hippocalcin protein and nearly identical to the rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation and may be of relevance for neuronal signalling in the central nervous system. Several alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307845
  • ENSP00000310749
  • ENSG00000115756
  • ENST00000381765
  • ENSP00000371184
  • ENST00000613496
  • ENSP00000478231
  • ENST00000620771
  • ENSP00000483786
  • ENST00000622018
  • ENSP00000482993

Symbol
  • BDR1
  • BDR1
  • HLP2
  • VILIP-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
disease perturbation
0.9
transcription factor binding site profile
0.84
kinase perturbation
0.76
transcription factor
0.76


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.85   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.85   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hippocalcin like 1
VGNC:6392
459026
Macaque
hippocalcin like 1
695395
Mouse
MGI:1855689
53602
Rat
RGD:708375
50871
Dog
hippocalcin like 1
VGNC:41768
609787
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hippocalcin like 1
Macaque
hippocalcin like 1
Mouse
Rat
Dog
hippocalcin like 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P37235-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (57)
1 – 10 of 57
CYP1A1
Tchem
Novelty: 0.0002404
p_int: 0.999980539
p_ni: 0.000019349
p_wrong: 1.11e-7
Data Source: BioPlex
SLC25A41
Tdark
Family: Transporter
Novelty: 1.04918395
p_int: 0.999462894
p_ni: 0.000535679
p_wrong: 0.000001427
Data Source: BioPlex
HAX1
Tbio
Novelty: 0.00749205
p_int: 0.999293536
p_ni: 0.000706434
p_wrong: 3e-8
Data Source: BioPlex
ACBD7
Tdark
Novelty: 0.32019061
p_int: 0.998832997
p_ni: 0.001165664
p_wrong: 0.000001339
Score: 0.169
Data Source: BioPlex,STRINGDB
SLC39A9
Tbio
Family: Transporter
Novelty: 0.06143625
p_int: 0.998003165
p_ni: 0.001996561
p_wrong: 2.74e-7
Data Source: BioPlex
DGUOK
Tbio
Family: Kinase
Novelty: 0.00897987
p_int: 0.997366099
p_ni: 0.002630994
p_wrong: 0.000002907
Data Source: BioPlex
TMEM185A
Tdark
Novelty: 0.0262898
p_int: 0.996912798
p_ni: 0.003080024
p_wrong: 0.000007178
Data Source: BioPlex
DPEP1
Tclin
Family: Enzyme
Novelty: 0.00384946
p_int: 0.996901436
p_ni: 0.003048376
p_wrong: 0.000050188
Data Source: BioPlex
S1PR2
Tchem
Family: GPCR
Novelty: 0.00372765
p_int: 0.995221222
p_ni: 0.004752144
p_wrong: 0.000026634
Data Source: BioPlex
MGLL
Tchem
Family: Enzyme
Novelty: 0.00196912
p_int: 0.994023609
p_ni: 0.005884595
p_wrong: 0.000091797
Score: 0.312
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  24.85

PubMed score by year
PubTator Score  20.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer