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Tclin
PPARG
Peroxisome proliferator-activated receptor gamma

Protein Summary
Description
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity). (Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein. This gene encodes a member of the peroxisome proliferator-acti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287820
  • ENSP00000287820
  • ENSG00000132170
  • ENST00000309576
  • ENSP00000312472
  • ENST00000396999
  • ENSP00000380195
  • ENST00000397010
  • ENSP00000380205
  • ENST00000397012
  • ENSP00000380207
  • ENST00000397015
  • ENSP00000380210
  • ENST00000643197
  • ENSP00000495840
  • ENST00000643888
  • ENSP00000494934
  • ENST00000644622
  • ENSP00000494873

Symbol
  • NR1C3
  • GLM1
  • CIMT1
  • NR1C3
  • PPARG1
  • PPARG2
  • PPARgamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
molecular function
1
drug
0.99
ligand (chemical)
0.98


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12245.77   (req: < 5)
Gene RIFs: 1518   (req: <= 3)
Antibodies: 986   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12245.77   (req: >= 5)
Gene RIFs: 1518   (req: > 3)
Antibodies: 986   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 113
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1357
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (577)
FLYWCH2
Tdark
Novelty:  1.44186144
p_int:  0.980820823
p_ni:  0.019179176
Score:  0.282
Data Source:  BioPlex,STRINGDB
PPARGC1A
Tbio
Novelty:  0.0003625
Score:  0.999
Data Source:  STRINGDB
CREBBP
Tchem
Family:  Epigenetic
Novelty:  0.00111166
Score:  0.998
Data Source:  STRINGDB
NCOA1
Tchem
Family:  Epigenetic
Novelty:  0.00344663
Score:  0.998
Data Source:  STRINGDB
NCOA2
Tbio
Novelty:  0.00510052
Score:  0.998
Data Source:  STRINGDB
RXRA
Tclin
Family:  NR
Novelty:  0.00244343
Score:  0.997
Data Source:  Reactome,STRINGDB
ADIPOQ
Tbio
Novelty:  0.00011196
Score:  0.994
Data Source:  STRINGDB
FABP4
Tchem
Novelty:  0.00107707
Score:  0.991
Data Source:  STRINGDB
LEP
Tbio
Novelty:  0.00005295
Score:  0.991
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.99
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (54)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Intracellular signaling by second messengers
Reactome
MECP2 regulates transcription factors
Name
Explore in Pharos
Explore in Source
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Intracellular signaling by second messengers
MECP2 regulates transcription factors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (120)
Find Similar Targets
Items per page:
10
1 – 10 of 36
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Disease Associations (null)
No disease associations found
GWAS Traits (92)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
16
9
6
1.1
99.4
BMI-adjusted waist-hip ratio
8
42
88
98
low density lipoprotein cholesterol measurement
8
7
10
97.8
platelet count
7
7
6
2
97.2
BMI-adjusted hip circumference
3
31
47
96.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
6
1.1
99.4
BMI-adjusted waist-hip ratio
88
98
low density lipoprotein cholesterol measurement
10
97.8
platelet count
6
2
97.2
BMI-adjusted hip circumference
47
96.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peroxisome proliferator activated receptor gamma
VGNC:7994
460178
Macaque
peroxisome proliferator activated receptor gamma
574190
Mouse
MGI:97747
19016
Rat
RGD:3371
25664
Dog
peroxisome proliferator activated receptor gamma
VGNC:44836
403606
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peroxisome proliferator activated receptor gamma
Macaque
peroxisome proliferator activated receptor gamma
Mouse
Rat
Dog
peroxisome proliferator activated receptor gamma
Publication Statistics
PubMed Score 12245.77
PubMed score by year
PubTator Score 5313.06
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title