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Tclin
PPARG
Peroxisome proliferator-activated receptor gamma

Protein Classes
Protein Summary
Description
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity). (Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein. This gene encodes a member of the peroxisome proliferator-acti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287820
  • ENSP00000287820
  • ENSG00000132170
  • ENST00000309576
  • ENSP00000312472
  • ENST00000396999
  • ENSP00000380195
  • ENST00000397010
  • ENSP00000380205
  • ENST00000397012
  • ENSP00000380207
  • ENST00000397015
  • ENSP00000380210
  • ENST00000643197
  • ENSP00000495840
  • ENST00000643888
  • ENSP00000494934
  • ENST00000644622
  • ENSP00000494873

Symbol
  • NR1C3
  • GLM1
  • CIMT1
  • NR1C3
  • PPARG1
  • PPARG2
  • PPARgamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
molecular function
1
drug
0.99
ligand (chemical)
0.98


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11040.68   (req: < 5)
Gene RIFs: 1518   (req: <= 3)
Antibodies: 986   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11040.68   (req: >= 5)
Gene RIFs: 1518   (req: > 3)
Antibodies: 986   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 113
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 938
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
15
8
4
1.1
99.5
sex hormone-binding globulin measurement
6
2
6
99.2
BMI-adjusted waist-hip ratio
6
3
9
98.7
body mass index
4
3
4
96.7
body fat percentage
1
1
3
90.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
99.5
sex hormone-binding globulin measurement
6
99.2
BMI-adjusted waist-hip ratio
9
98.7
body mass index
4
96.7
body fat percentage
3
90.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peroxisome proliferator activated receptor gamma
VGNC:7994
460178
Macaque
peroxisome proliferator activated receptor gamma
574190
Mouse
MGI:97747
19016
Rat
RGD:3371
25664
Dog
peroxisome proliferator activated receptor gamma
VGNC:44836
403606
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peroxisome proliferator activated receptor gamma
Macaque
peroxisome proliferator activated receptor gamma
Mouse
Rat
Dog
peroxisome proliferator activated receptor gamma
Protein Structure (177 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P37231-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 177
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (54)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Intracellular signaling by second messengers
Reactome
MECP2 regulates transcription factors
Name
Explore in Pharos
Explore in Source
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Intracellular signaling by second messengers
MECP2 regulates transcription factors
Gene Ontology Terms (120)
Items per page:
10
1 – 10 of 36
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Protein-Protein Interactions (577)
1 – 10 of 577
FLYWCH2
Tdark
Novelty: 1.44186144
p_int: 0.980820823
p_ni: 0.019179176
Score: 0.282
Data Source: BioPlex,STRINGDB
PPARGC1A
Tbio
Novelty: 0.0003625
Score: 0.999
Data Source: STRINGDB
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00111166
Score: 0.998
Data Source: STRINGDB
NCOA1
Tchem
Family: Epigenetic
Novelty: 0.00344663
Score: 0.998
Data Source: STRINGDB
NCOA2
Tbio
Novelty: 0.00510052
Score: 0.998
Data Source: STRINGDB
RXRA
Tclin
Family: NR
Novelty: 0.00244343
Score: 0.997
Data Source: Reactome,STRINGDB
ADIPOQ
Tbio
Novelty: 0.00011196
Score: 0.994
Data Source: STRINGDB
FABP4
Tchem
Novelty: 0.00107707
Score: 0.991
Data Source: STRINGDB
LEP
Tbio
Novelty: 0.00005295
Score: 0.991
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.99
Data Source: STRINGDB
Publication Statistics
PubMed Score  11040.68

PubMed score by year
PubTator Score  5313.06

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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