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Tchem
TGFBR2
TGF-beta receptor type-2

Protein Summary
Description
Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295754
  • ENSP00000295754
  • ENSG00000163513
  • ENST00000359013
  • ENSP00000351905

Symbol
  • AAT3
  • FAA3
  • LDS2
  • MFS2
  • RIIC
  • LDS1B
  • LDS2B
  • TAAD2
  • TBRII
  • TBR-ii
  • TGFR-2
  • TGFbeta-RII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
hub protein
0.99
PubMedID
0.98
transcription factor perturbation
0.98


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1115.67   (req: < 5)
Gene RIFs: 349   (req: <= 3)
Antibodies: 734   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1115.67   (req: >= 5)
Gene RIFs: 349   (req: > 3)
Antibodies: 734   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 84
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
82.3
2
1
0
1.1
41.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
82.3
0
1.1
41.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transforming growth factor beta receptor 2
VGNC:9701
460243
Macaque
transforming growth factor beta receptor 2
703088
Mouse
MGI:98729
21813
Rat
RGD:69651
81810
Dog
transforming growth factor beta receptor 2
VGNC:47312
477039
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transforming growth factor beta receptor 2
Macaque
transforming growth factor beta receptor 2
Mouse
Rat
Dog
transforming growth factor beta receptor 2
Protein Structure (13 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P37173-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (123)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downregulation of TGF-beta receptor signaling
Reactome
Loss of Function of SMAD2/3 in Cancer
Name
Explore in Pharos
Explore in Source
Deubiquitination
Disease
Diseases of signal transduction
Downregulation of TGF-beta receptor signaling
Loss of Function of SMAD2/3 in Cancer
Gene Ontology Terms (92)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (252)
1 – 10 of 252
FMN2
Tbio
Novelty: 0.02031944
p_int: 0.999778831
p_ni: 0.000219207
p_wrong: 0.000001962
Score: 0.233
Data Source: BioPlex,STRINGDB
ACVR2B
Tchem
Family: Kinase
Novelty: 0.00555742
p_int: 0.999678794
p_ni: 0.000314222
p_wrong: 0.000006985
Score: 0.189
Data Source: BioPlex,STRINGDB
BMPR1A
Tchem
Family: Kinase
Novelty: 0.00343928
p_int: 0.99953362
p_ni: 0.00046638
Score: 0.657
Data Source: BioPlex,STRINGDB
MYADM
Tbio
Novelty: 0.11475375
p_int: 0.999418203
p_ni: 0.000580601
p_wrong: 0.000001196
Data Source: BioPlex
DENND6A
Tbio
Novelty: 4.5572617
p_int: 0.998203843
p_ni: 0.001796156
p_wrong: 1e-9
Data Source: BioPlex
RELT
Tbio
Novelty: 0.07977949
p_int: 0.990789375
p_ni: 0.002299616
p_wrong: 0.006911009
Score: 0.226
Data Source: BioPlex,STRINGDB
RAB6B
Tbio
Family: Enzyme
Novelty: 0.0865097
p_int: 0.986593271
p_ni: 0.013406669
p_wrong: 6e-8
Data Source: BioPlex
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
p_int: 0.974123871
p_ni: 0.025876129
Score: 0.241
Data Source: BioPlex,STRINGDB
PLEKHH3
Tdark
Novelty: 2.43915121
p_int: 0.969212294
p_ni: 0.030787706
Score: 0.199
Data Source: BioPlex,STRINGDB
PIK3R1
Tchem
Family: Kinase
Novelty: 0.00179772
p_int: 0.944480495
p_ni: 0.055519505
Score: 0.676
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1115.67

PubMed score by year
PubTator Score  653.46

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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