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Tbio
SRP14
Signal recognition particle 14 kDa protein

Protein Summary
Description
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267884
  • ENSP00000267884
  • ENSG00000140319

Symbol
  • ALURBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
co-expressed gene
0.97
kinase perturbation
0.93
transcription factor perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.11   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.11   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
1
1
32.2
reticulocyte count
1
1
1
19.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
32.2
reticulocyte count
1
19.8
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
signal recognition particle 14
VGNC:1871
737573
Macaque
signal recognition particle 14
701353
Mouse
MGI:107169
20813
Rat
RGD:1308506
296076
Dog
signal recognition particle 14
403930
Species
Name
OMA
EggNOG
Inparanoid
Chimp
signal recognition particle 14
Macaque
signal recognition particle 14
Mouse
Rat
Dog
signal recognition particle 14
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P37108-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Reactome
Neutrophil degranulation
Reactome
SRP-dependent cotranslational protein targeting to membrane
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism of proteins
Neutrophil degranulation
SRP-dependent cotranslational protein targeting to membrane
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (193)
1 – 10 of 193
SRP9
Tbio
Novelty: 0.02243103
p_int: 0.999986306
p_ni: 0.000013694
Score: 0.999
Data Source: BioPlex,STRINGDB
SRP68
Tbio
Novelty: 0.04666697
p_int: 0.976389171
p_ni: 0.023610829
Score: 0.999
Data Source: BioPlex,STRINGDB
SRP54
Tbio
Novelty: 0.00535567
Score: 0.999
Data Source: STRINGDB
SRP19
Tbio
Novelty: 0.01831843
Score: 0.999
Data Source: STRINGDB
SRP72
Tbio
Novelty: 0.03264445
Score: 0.999
Data Source: STRINGDB
RPL9
Tbio
Novelty: 0.00845583
Score: 0.998
Data Source: STRINGDB
RPL27
Tbio
Novelty: 0.0157566
Score: 0.998
Data Source: STRINGDB
RPL35A
Tbio
Novelty: 0.04968098
Score: 0.998
Data Source: STRINGDB
RPS25
Tbio
Novelty: 0.02812798
Score: 0.998
Data Source: STRINGDB
RPS27
Tchem
Novelty: 0.02805495
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.11

PubMed score by year
PubTator Score  26.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer