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Tchem
HSD17B2
Estradiol 17-beta-dehydrogenase 2

Protein Summary
Description
Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000199936
  • ENSP00000199936
  • ENSG00000086696

Symbol
  • EDH17B2
  • SDR9C2
  • HSD17
  • SDR9C2
  • EDH17B2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
phenotype
0.8
virus perturbation
0.79
PubMedID
0.74
disease
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.67   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.67   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 414
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
masoprocol
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Active Ligands (414)
1 – 10 of 414
Kaempferol
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nordihydroguiaretic acid
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CHEMBL1650646
Rendered image for CHEMBL1650646
CHEMBL577338
Rendered image for CHEMBL577338
CHEMBL4071245
Rendered image for CHEMBL4071245
CHEMBL4072794
Rendered image for CHEMBL4072794
CHEMBL4102153
Rendered image for CHEMBL4102153
CHEMBL4099681
Rendered image for CHEMBL4099681
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
3
1
3
67.1
mean platelet volume
1
1
1
64.9
telomere length
2
2
2
56
testosterone measurement
1
1
1
26.6
1
1
0
1.1
5.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
3
67.1
mean platelet volume
1
64.9
telomere length
2
56
testosterone measurement
1
26.6
0
1.1
5.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hydroxysteroid 17-beta dehydrogenase 2
VGNC:13715
454269
Mouse
MGI:1096386
15486
Rat
RGD:621803
79243
Dog
hydroxysteroid 17-beta dehydrogenase 2
VGNC:41805
489690
Cow
hydroxysteroid 17-beta dehydrogenase 2
VGNC:29973
515710
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hydroxysteroid 17-beta dehydrogenase 2
Mouse
Rat
Dog
hydroxysteroid 17-beta dehydrogenase 2
Cow
hydroxysteroid 17-beta dehydrogenase 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P37059-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Estrogen biosynthesis (R-HSA-193144)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Estrogen biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroid hormones
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Estrogen biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroid hormones
Metabolism of steroids
Protein-Protein Interactions (84)
1 – 10 of 84
ERGIC2
Tbio
Novelty:  0.08610944
p_int:  0.774760044
p_ni:  0.225239922
p_wrong:  3.4e-8
Score:  0.534
Data Source:  BioPlex,STRINGDB
HSD17B3
Tchem
Family:  Enzyme
Novelty:  0.00666322
Score:  0.979
Data Source:  STRINGDB
SULT1E1
Tchem
Family:  Enzyme
Novelty:  0.00245381
Score:  0.967
Data Source:  STRINGDB
HSD17B1
Tchem
Family:  Enzyme
Novelty:  0.00313425
Score:  0.966
Data Source:  STRINGDB
CYP19A1
Tclin
Family:  Enzyme
Novelty:  0.0003187
Score:  0.962
Data Source:  STRINGDB
SRD5A1
Tclin
Family:  Enzyme
Novelty:  0.00987219
Score:  0.962
Data Source:  STRINGDB
HSD3B1
Tchem
Family:  Enzyme
Novelty:  0.0019271
Score:  0.961
Data Source:  STRINGDB
HSD3B2
Tclin
Family:  Enzyme
Novelty:  0.00711552
Score:  0.961
Data Source:  STRINGDB
CYP17A1
Tclin
Family:  Enzyme
Novelty:  0.00065091
Score:  0.96
Data Source:  STRINGDB
SRD5A2
Tclin
Family:  Enzyme
Novelty:  0.00281044
Score:  0.954
Data Source:  STRINGDB
Publication Statistics
PubMed Score  99.67

PubMed score by year
PubTator Score  89.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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