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Tchem
HSD17B3
Testosterone 17-beta-dehydrogenase 3

Protein Summary
Description
Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH. This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375262
  • ENSP00000364411
  • ENSG00000130948
  • ENST00000375263
  • ENSP00000364412

Symbol
  • EDH17B3
  • SDR12C2
  • EDH17B3
  • SDR12C2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.73
protein domain
0.58
co-expressed gene
0.57
disease
0.52
cellular component
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.73   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.73   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 152
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (152)
etiocholanolone
Rendered image for etiocholanolone
CHEMBL206167
Rendered image for CHEMBL206167
CHEMBL206384
Rendered image for CHEMBL206384
CHEMBL206432
Rendered image for CHEMBL206432
CHEMBL204882
Rendered image for CHEMBL204882
CHEMBL206405
Rendered image for CHEMBL206405
CHEMBL2018254
Rendered image for CHEMBL2018254
CHEMBL383546
Rendered image for CHEMBL383546
CHEMBL589158
Rendered image for CHEMBL589158
Protein-Protein Interactions (88)
POTEI
Tdark
Novelty:  0.41311202
p_int:  0.999901939
p_ni:  0.000098061
Score:  0.184
Data Source:  BioPlex,STRINGDB
PCP2
Tdark
Novelty:  0.05083955
p_int:  0.953800799
p_ni:  0.038680862
p_wrong:  0.007518339
Score:  0.243
Data Source:  BioPlex,STRINGDB
HERC3
Tbio
Family:  Enzyme
Novelty:  0.05231675
p_int:  0.944820796
p_ni:  0.055179204
Data Source:  BioPlex
AHNAK
Tbio
Novelty:  0.01201996
p_int:  0.928156287
p_ni:  0.071843713
Score:  0.167
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.926561437
p_ni:  0.073438563
Data Source:  BioPlex
AMFR
Tbio
Family:  Enzyme
Novelty:  0.00533547
p_int:  0.883467312
p_ni:  0.116532688
Score:  0.226
Data Source:  BioPlex,STRINGDB
NCS1
Tbio
Novelty:  0.0051468
p_int:  0.868502955
p_ni:  0.13147851
p_wrong:  0.000018535
Score:  0.234
Data Source:  BioPlex,STRINGDB
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.867512048
p_ni:  0.132487952
Score:  0.252
Data Source:  BioPlex,STRINGDB
CYP17A1
Tclin
Family:  Enzyme
Novelty:  0.00065091
Score:  0.98
Data Source:  STRINGDB
HSD17B2
Tchem
Family:  Enzyme
Novelty:  0.00960865
Score:  0.979
Data Source:  STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
1 – 5 of 6
HSD3B2
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
CYP11B1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
SRD5A1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  1
SRD5A2
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  1
CYP17A1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (16)
Androgen biosynthesis (R-HSA-193048)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Androgen biosynthesis
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Androgen biosynthesis
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
5
7
89.9
self reported educational attainment
2
2
2
75.7
mean corpuscular hemoglobin concentration
1
1
1
66.3
BMI-adjusted waist circumference
1
1
1
62.1
mean platelet volume
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
7
89.9
self reported educational attainment
2
75.7
mean corpuscular hemoglobin concentration
1
66.3
BMI-adjusted waist circumference
1
62.1
mean platelet volume
1
57.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hydroxysteroid 17-beta dehydrogenase 3
VGNC:13894
742116
Macaque
hydroxysteroid 17-beta dehydrogenase 3
709843
Mouse
MGI:107177
15487
Rat
RGD:621805
117182
Dog
hydroxysteroid 17-beta dehydrogenase 3
VGNC:41806
100856708
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hydroxysteroid 17-beta dehydrogenase 3
Macaque
hydroxysteroid 17-beta dehydrogenase 3
Mouse
Rat
Dog
hydroxysteroid 17-beta dehydrogenase 3
Publication Statistics
PubMed Score 145.73
PubMed score by year
PubTator Score 81.72
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title