ACVRL1
Serine/threonine-protein kinase receptor R3
Protein Summary
Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangie ...more
- ENST00000388922
- ENSP00000373574
- ENSG00000139567
- ACVRLK1
- ALK1
- HHT
- ALK1
- HHT2
- ORW2
- SKR3
- ALK-1
- TSR-I
- ACVRLK1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
molecular function | 1 | ||
protein domain | 0.92 | ||
disease perturbation | 0.79 | ||
biological term | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 383.6 (req: < 5)
Gene RIFs: 115 (req: <= 3)
Antibodies: 540 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 383.6 (req: >= 5)
Gene RIFs: 115 (req: > 3)
Antibodies: 540 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 60
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 54
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (54)
Protein-Protein Interactions (103)
PDXDC2P
Family: Enzyme
p_int: 0.982542538
p_ni: 0.016176108
p_wrong: 0.001281354
Data Source: BioPlex
SLC25A24
Family: Transporter
Novelty: 0.06151955
p_int: 0.958455576
p_ni: 0.036005985
p_wrong: 0.005538439
Score: 0.228
Data Source: BioPlex,STRINGDB
ACVR1
Family: Kinase
Novelty: 0.00284646
p_int: 0.874917456
p_ni: 8e-9
p_wrong: 0.125082536
Score: 0.546
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (56)
Reactome (3)
KEGG (1)
PathwayCommons (13)
WikiPathways (39)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Signal Transduction | ||||
Reactome | Signaling by BMP | ||||
Reactome | Signaling by TGF-beta family members | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Signal Transduction | ||||
Signaling by BMP | ||||
Signaling by TGF-beta family members | ||||
Viral Interactions (0)
Gene Ontology Terms (67)
Functions (13)
Components (7)
Processes (47)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Disease Associations ()
GWAS Traits (23)
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neutrophil count | 3 | 2 | 3 | 84.7 | |||||
hematocrit | 4 | 3 | 4 | 84.3 | |||||
myeloid white cell count | 2 | 1 | 2 | 78.5 | |||||
urate measurement | 4 | 4 | 4 | 75 | |||||
platelet crit | 2 | 1 | 2 | 73.7 | |||||
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neutrophil count | 3 | 84.7 | |||||
hematocrit | 4 | 84.3 | |||||
myeloid white cell count | 2 | 78.5 | |||||
urate measurement | 4 | 75 | |||||
platelet crit | 2 | 73.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | activin A receptor like type 1 | VGNC:8313 | 451910 | |||||
Macaque | activin A receptor like type 1 | 696471 | ||||||
Mouse | MGI:1338946 | 11482 | ||||||
Rat | RGD:2029 | 25237 | ||||||
Dog | activin A receptor like type 1 | VGNC:37566 | 477603 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | activin A receptor like type 1 | |||||
Macaque | activin A receptor like type 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | activin A receptor like type 1 | |||||
Publication Statistics
PubMed Score 383.60
PubMed score by year
PubTator Score 310.99
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (151)
GeneRif Annotations (115)
Items per page:
0 of 0
PMID | Year | Title |
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