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Tchem
ACVRL1
Serine/threonine-protein kinase receptor R3

Protein Classes
Protein Summary
Description
Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangie ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000388922
  • ENSP00000373574
  • ENSG00000139567

Symbol
  • ACVRLK1
  • ALK1
  • HHT
  • ALK1
  • HHT2
  • ORW2
  • SKR3
  • ALK-1
  • TSR-I
  • ACVRLK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
0.92
disease perturbation
0.79
biological term
0.78


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 374.56   (req: < 5)
Gene RIFs: 115   (req: <= 3)
Antibodies: 540   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 374.56   (req: >= 5)
Gene RIFs: 115   (req: > 3)
Antibodies: 540   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 60
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 46
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (46)
1 – 10 of 46
CHEMBL1241674
chemical structure image
CHEMBL2385579
chemical structure image
CHEMBL2385582
chemical structure image
CHEMBL2385596
chemical structure image
CHEMBL1980995
chemical structure image
panulisib
chemical structure image
CHEMBL3818173
chemical structure image
CHEMBL3671320
chemical structure image
CHEMBL3671318
chemical structure image
CHEMBL3341789
chemical structure image
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
1
2
79.4
hematocrit
3
2
3
78.9
neutrophil count
2
1
2
74.3
monocyte count
3
1
3
73.3
mean platelet volume
1
1
1
63.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
79.4
hematocrit
3
78.9
neutrophil count
2
74.3
monocyte count
3
73.3
mean platelet volume
1
63.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
activin A receptor like type 1
VGNC:8313
451910
Macaque
activin A receptor like type 1
696471
Mouse
MGI:1338946
11482
Rat
RGD:2029
25237
Dog
activin A receptor like type 1
VGNC:37566
477603
Species
Name
OMA
EggNOG
Inparanoid
Chimp
activin A receptor like type 1
Macaque
activin A receptor like type 1
Mouse
Rat
Dog
activin A receptor like type 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P37023-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (56)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by BMP
Reactome
Signaling by TGF-beta family members
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by BMP
Signaling by TGF-beta family members
Gene Ontology Terms (67)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (103)
1 – 10 of 103
PDXDC2P
Tdark
Family: Enzyme
p_int: 0.982542538
p_ni: 0.016176108
p_wrong: 0.001281354
Data Source: BioPlex
SLC25A24
Tbio
Family: Transporter
Novelty: 0.06151955
p_int: 0.958455576
p_ni: 0.036005985
p_wrong: 0.005538439
Score: 0.228
Data Source: BioPlex,STRINGDB
ACVR1
Tchem
Family: Kinase
Novelty: 0.00284646
p_int: 0.874917456
p_ni: 8e-9
p_wrong: 0.125082536
Score: 0.546
Data Source: BioPlex,STRINGDB
GDF2
Tbio
Novelty: 0.00433233
Score: 0.998
Data Source: Reactome,STRINGDB
ENG
Tbio
Novelty: 0.00036729
Score: 0.993
Data Source: STRINGDB
BMP10
Tbio
Novelty: 0.01860398
Score: 0.984
Data Source: Reactome,STRINGDB
ACVR2B
Tchem
Family: Kinase
Novelty: 0.00555742
Score: 0.976
Data Source: STRINGDB
SMAD1
Tbio
Family: TF
Novelty: 0.02348173
Score: 0.97
Data Source: STRINGDB
SMAD9
Tbio
Family: TF
Novelty: 0.00285887
Score: 0.969
Data Source: STRINGDB
TGFB1
Tchem
Novelty: 0.0001299
Score: 0.969
Data Source: STRINGDB
Publication Statistics
PubMed Score  374.56

PubMed score by year
PubTator Score  310.99

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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