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Tbio
GPX4
Phospholipid hydroperoxide glutathione peroxidase

Protein Summary
Description
Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (PubMed:24439385). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ing ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354171
  • ENSP00000346103
  • ENSG00000167468
  • ENST00000611653
  • ENSP00000483655

Symbol
  • MCSP
  • SMDS
  • GPx-4
  • PHGPx
  • snGPx
  • GSHPx-4
  • snPHGPx
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
transcription factor perturbation
0.97
disease
0.89
transcription factor binding site profile
0.89
PubMedID
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 582.93   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 317   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 582.93   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 317   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
2
1
2
54.9
eosinophil count
2
1
2
50.9
eosinophil percentage of granulocytes
1
1
1
26.2
1
1
0
1.1
22.7
leukocyte count
1
1
1
20
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
2
54.9
eosinophil count
2
50.9
eosinophil percentage of granulocytes
1
26.2
0
1.1
22.7
leukocyte count
1
20
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (25)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biosynthesis of D-series resolvins
Reactome
Biosynthesis of DHA-derived SPMs
Reactome
Biosynthesis of E-series 18(R)-resolvins
Reactome
Biosynthesis of E-series 18(S)-resolvins
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biosynthesis of D-series resolvins
Biosynthesis of DHA-derived SPMs
Biosynthesis of E-series 18(R)-resolvins
Biosynthesis of E-series 18(S)-resolvins
Protein-Protein Interactions (164)
1 – 10 of 164
GSTO2
Tbio
Family: Enzyme
Novelty: 0.01836256
p_int: 0.795811236
p_ni: 0.204188764
Score: 0.933
Data Source: BioPlex,STRINGDB
GRSF1
Tbio
Novelty: 0.05905648
Score: 0.985
Data Source: STRINGDB
GSR
Tclin
Family: Enzyme
Novelty: 0.00040107
Score: 0.985
Data Source: STRINGDB
GSS
Tbio
Family: Enzyme
Novelty: 0.03002278
Score: 0.951
Data Source: STRINGDB
SOD2
Tbio
Family: Enzyme
Novelty: 0.00084288
Score: 0.94
Data Source: STRINGDB
GGT7
Tbio
Family: Enzyme
Novelty: 0.01374716
Score: 0.919
Data Source: STRINGDB
GGT1
Tbio
Family: Enzyme
Novelty: 0.00252374
Score: 0.918
Data Source: STRINGDB
SOD1
Tbio
Family: Enzyme
Novelty: 0.00039653
Score: 0.917
Data Source: STRINGDB
GGT5
Tbio
Family: Enzyme
Novelty: 0.00602505
Score: 0.915
Data Source: STRINGDB
GGT6
Tbio
Family: Enzyme
Novelty: 0.016069
Score: 0.911
Data Source: STRINGDB
Publication Statistics
PubMed Score  582.93

PubMed score by year
PubTator Score  248.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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