Protein Summary
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides.[provided by RefSeq, Oct 2009]
- ENST00000259727
- ENSP00000259727
- ENSG00000137198
- GMPR1
- GMPR1
- GMPR 1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.76 | ||
virus perturbation | 0.72 | ||
small molecule perturbation | 0.7 | ||
transcription factor binding site profile | 0.66 | ||
tissue sample | 0.62 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.26 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 143 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.26 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 143 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 4 | 4 | 4 | 94.8 | |||||
hemoglobin measurement | 3 | 3 | 3 | 87.9 | |||||
mean corpuscular volume | 3 | 3 | 3 | 84.1 | |||||
red blood cell distribution width | 2 | 3 | 4 | 81.1 | |||||
reticulocyte count | 6 | 4 | 12 | 77.1 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 4 | 94.8 | |||||
hemoglobin measurement | 3 | 87.9 | |||||
mean corpuscular volume | 3 | 84.1 | |||||
red blood cell distribution width | 4 | 81.1 | |||||
reticulocyte count | 12 | 77.1 | |||||
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | guanosine monophosphate reductase | VGNC:11084 | 462453 | |||||
Macaque | guanosine monophosphate reductase | 710619 | ||||||
Mouse | MGI:1913605 | 66355 | ||||||
Rat | RGD:70980 | 117533 | ||||||
Dog | guanosine monophosphate reductase | VGNC:41294 | 488231 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | guanosine monophosphate reductase | |||||
Macaque | guanosine monophosphate reductase | |||||
Mouse | ||||||
Rat | ||||||
Dog | guanosine monophosphate reductase | |||||
Protein Structure (2 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (7)
Reactome (4)
KEGG (2)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of nucleotides | ||||
Reactome | Nucleotide salvage | ||||
Reactome | Purine salvage | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of nucleotides | ||||
Nucleotide salvage | ||||
Purine salvage | ||||
Gene Ontology Terms (8)
Functions (2)
Components (2)
Processes (4)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (106)
1 – 10 of 106
GMPR2
Family: Enzyme
Novelty: 0.16707153
p_int: 0.972635799
p_ni: 0.027364201
Score: 0.937
Data Source: BioPlex,STRINGDB
GMPS
Family: Enzyme
Novelty: 0.00611806
Score: 0.992
Data Source: STRINGDB
ADSS
Family: Enzyme
Novelty: 0.0126472
Score: 0.967
Data Source: STRINGDB
APRT
Family: Enzyme
Novelty: 0.00483077
Score: 0.959
Data Source: STRINGDB
ADSSL1
Family: Enzyme
Novelty: 0.0511949
Score: 0.958
Data Source: STRINGDB
AMPD3
Family: Enzyme
Novelty: 0.01230806
Score: 0.955
Data Source: STRINGDB
ITPA
Family: Enzyme
Novelty: 0.00235169
Score: 0.951
Data Source: STRINGDB
AMPD2
Family: Enzyme
Novelty: 0.01510718
Score: 0.948
Data Source: STRINGDB
ATIC
Novelty: 0.00466845
Score: 0.94
Data Source: STRINGDB
AMPD1
Family: Enzyme
Novelty: 0.00486439
Score: 0.937
Data Source: STRINGDB
Publication Statistics
PubMed Score 30.26
PubMed score by year
PubTator Score 13.37
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword