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Tbio
GMPR
GMP reductase 1

Protein Summary
Description
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides.[provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259727
  • ENSP00000259727
  • ENSG00000137198

Symbol
  • GMPR1
  • GMPR1
  • GMPR 1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.76
virus perturbation
0.72
small molecule perturbation
0.7
transcription factor binding site profile
0.66
tissue sample
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.26   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.26   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
4
4
4
94.8
hemoglobin measurement
3
3
3
87.9
mean corpuscular volume
3
3
3
84.1
red blood cell distribution width
2
3
4
81.1
reticulocyte count
6
4
12
77.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
4
94.8
hemoglobin measurement
3
87.9
mean corpuscular volume
3
84.1
red blood cell distribution width
4
81.1
reticulocyte count
12
77.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
guanosine monophosphate reductase
VGNC:11084
462453
Macaque
guanosine monophosphate reductase
710619
Mouse
MGI:1913605
66355
Rat
RGD:70980
117533
Dog
guanosine monophosphate reductase
VGNC:41294
488231
Species
Name
OMA
EggNOG
Inparanoid
Chimp
guanosine monophosphate reductase
Macaque
guanosine monophosphate reductase
Mouse
Rat
Dog
guanosine monophosphate reductase
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P36959-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleotide salvage
Reactome
Purine salvage
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleotide salvage
Purine salvage
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (106)
1 – 10 of 106
GMPR2
Tbio
Family: Enzyme
Novelty: 0.16707153
p_int: 0.972635799
p_ni: 0.027364201
Score: 0.937
Data Source: BioPlex,STRINGDB
GMPS
Tbio
Family: Enzyme
Novelty: 0.00611806
Score: 0.992
Data Source: STRINGDB
ADSS
Tchem
Family: Enzyme
Novelty: 0.0126472
Score: 0.967
Data Source: STRINGDB
APRT
Tbio
Family: Enzyme
Novelty: 0.00483077
Score: 0.959
Data Source: STRINGDB
ADSSL1
Tbio
Family: Enzyme
Novelty: 0.0511949
Score: 0.958
Data Source: STRINGDB
AMPD3
Tchem
Family: Enzyme
Novelty: 0.01230806
Score: 0.955
Data Source: STRINGDB
ITPA
Tbio
Family: Enzyme
Novelty: 0.00235169
Score: 0.951
Data Source: STRINGDB
AMPD2
Tchem
Family: Enzyme
Novelty: 0.01510718
Score: 0.948
Data Source: STRINGDB
ATIC
Tchem
Novelty: 0.00466845
Score: 0.94
Data Source: STRINGDB
AMPD1
Tchem
Family: Enzyme
Novelty: 0.00486439
Score: 0.937
Data Source: STRINGDB
Publication Statistics
PubMed Score  30.26

PubMed score by year
PubTator Score  13.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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