Protein Summary
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides.[provided by RefSeq, Oct 2009]
- ENST00000259727
- ENSP00000259727
- ENSG00000137198
- GMPR1
- GMPR1
- GMPR 1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.76 | ||
virus perturbation | 0.72 | ||
small molecule perturbation | 0.7 | ||
transcription factor binding site profile | 0.66 | ||
tissue sample | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.89 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 143 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.89 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 143 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (106)
GMPR2
Family: Enzyme
Novelty: 0.16707153
p_int: 0.972635799
p_ni: 0.027364201
Score: 0.937
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (46)
Upstream (30)
Downstream (16)
1 – 5 of 30
Pathways (7)
Reactome (4)
KEGG (2)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of nucleotides | ||||
Reactome | Nucleotide salvage | ||||
Reactome | Purine salvage | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of nucleotides | ||||
Nucleotide salvage | ||||
Purine salvage | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (2)
Components (2)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 4 | 4 | 4 | 98.4 | |||||
reticulocyte measurement | 3 | 5 | 9 | 96.7 | |||||
reticulocyte count | 6 | 5 | 16 | 95.6 | |||||
hemoglobin measurement | 3 | 3 | 3 | 92.2 | |||||
mean corpuscular volume | 3 | 3 | 3 | 89.1 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 4 | 98.4 | |||||
reticulocyte measurement | 9 | 96.7 | |||||
reticulocyte count | 16 | 95.6 | |||||
hemoglobin measurement | 3 | 92.2 | |||||
mean corpuscular volume | 3 | 89.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | guanosine monophosphate reductase | VGNC:11084 | 462453 | |||||
Macaque | guanosine monophosphate reductase | 710619 | ||||||
Mouse | MGI:1913605 | 66355 | ||||||
Rat | RGD:70980 | 117533 | ||||||
Dog | guanosine monophosphate reductase | VGNC:41294 | 488231 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | guanosine monophosphate reductase | |||||
Macaque | guanosine monophosphate reductase | |||||
Mouse | ||||||
Rat | ||||||
Dog | guanosine monophosphate reductase | |||||
Publication Statistics
PubMed Score 30.89
PubMed score by year
PubTator Score 13.37
PubTator score by year
Related Publications
Text Mined References (25)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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