Tbio DLST Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

Protein Summary

Description

Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (By similarity). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711). This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• P36957
• B7Z5W8
• E7ESY5
• Q7LDY7
• Q9BQ32

Gene Name

• DLST

Ensembl ID

• ENST00000334220
• ENSP00000335304
• ENSG00000119689

Symbol

• DLTS
• DLTS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	0.98
disease perturbation	0.96
protein domain	0.85
transcription factor binding site profile	0.75
transcription factor perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Dihydrolipoyllysine-residue Succinyltransferase Component Of 2-oxoglutarate Dehydrogenase Complex, Mitochondrial

Protein / Transferase / Acetyltransferase / Dihydrolipoyllysine-residue Succinyltransferase Component Of 2-oxoglutarate Dehydrogenase Complex, Mitochondrial

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / Dihydrolipoyllysine-residue Succinyltransferase Component Of 2-oxoglutarate Dehydrogenase Complex, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.05   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 190   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.05   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0