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Tbio
SREBF1
Sterol regulatory element-binding protein 1

Protein Summary
Description
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261646
  • ENSP00000261646
  • ENSG00000072310
  • ENST00000355815
  • ENSP00000348069

Symbol
  • BHLHD1
  • SREBP1
  • SREBP1
  • bHLHd1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease perturbation
1
chemical
0.93
kinase
0.92
biological term
0.9


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1896.99   (req: < 5)
Gene RIFs: 269   (req: <= 3)
Antibodies: 563   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1896.99   (req: >= 5)
Gene RIFs: 269   (req: > 3)
Antibodies: 563   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (357)
PVALB
Tbio
Novelty:  0.00024439
p_int:  0.998504372
p_ni:  0.00147592
p_wrong:  0.000019707
Score:  0.693
Data Source:  BioPlex,STRINGDB
SORL1
Tbio
Novelty:  0.00380895
p_int:  0.953990147
p_ni:  0.046009853
Score:  0.206
Data Source:  BioPlex,STRINGDB
LDLR
Tchem
Novelty:  0.06585434
Score:  0.983
Data Source:  STRINGDB
SCAP
Tbio
Novelty:  0.01021709
Score:  0.973
Data Source:  Reactome,STRINGDB
MBTPS2
Tbio
Family:  Enzyme
Novelty:  0.00625665
Score:  0.973
Data Source:  Reactome,STRINGDB
MTOR
Tclin
Family:  Kinase
Novelty:  0.00012333
Score:  0.972
Data Source:  STRINGDB
HMGCS1
Tchem
Family:  Enzyme
Novelty:  0.01089288
Score:  0.97
Data Source:  STRINGDB
MBTPS1
Tchem
Family:  Enzyme
Novelty:  0.00845881
Score:  0.956
Data Source:  Reactome,STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.955
Data Source:  STRINGDB
FASN
Tchem
Family:  Enzyme
Novelty:  0.00142172
Score:  0.954
Data Source:  STRINGDB
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
Pathways (38)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
Circadian Clock
Reactome
Developmental Biology
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
Circadian Clock
Developmental Biology
FOXO-mediated transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (55)
Find Similar Targets
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
HGNC
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
7
7
89.1
BMI-adjusted waist-hip ratio
2
7
7
88.2
lymphocyte count
2
2
2
86.8
sex hormone-binding globulin measurement
2
1
2
81.9
4
3
3
1.1
77.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
7
89.1
BMI-adjusted waist-hip ratio
7
88.2
lymphocyte count
2
86.8
sex hormone-binding globulin measurement
2
81.9
3
1.1
77.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
sterol regulatory element binding transcription factor 1
706972
Mouse
MGI:107606
20787
Rat
RGD:69423
78968
Dog
sterol regulatory element binding transcription factor 1
VGNC:46795
403475
Horse
sterol regulatory element binding transcription factor 1
VGNC:23576
100052283
Species
Name
OMA
EggNOG
Inparanoid
Macaque
sterol regulatory element binding transcription factor 1
Mouse
Rat
Dog
sterol regulatory element binding transcription factor 1
Horse
sterol regulatory element binding transcription factor 1
Publication Statistics
PubMed Score 1896.99
PubMed score by year
PubTator Score 732.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title