Tbio SREBF1 Sterol regulatory element-binding protein 1

Protein Summary

Description

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017]

Uniprot Accession IDs

• P36956
• B0I4X3
• B0I4X4
• D3DXC4
• Q16062
• Q59F52
• Q6P4R7
• Q6PFW7
• Q6PJ36
• Q8TAK9
• SREBP-1

Gene Name

• SREBF1

Ensembl ID

• ENST00000261646
• ENSP00000261646
• ENSG00000072310
• ENST00000355815
• ENSP00000348069

Symbol

• BHLHD1
• SREBP1
• SREBP1
• bHLHd1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
disease perturbation	1
chemical	0.93
kinase	0.92
biological term	0.9

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1896.99   (req: < 5)

Gene RIFs: 269   (req: <= 3)

Antibodies: 563   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1896.99   (req: >= 5)

Gene RIFs: 269   (req: > 3)

Antibodies: 563   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (357)

Explore Interacting Targets

1 – 10 of 357

• See Interactions on String-DB

PVALB

Tbio

Novelty:  0.00024439

p_int:  0.998504372

p_ni:  0.00147592

p_wrong:  0.000019707

Score:  0.693

Data Source:  BioPlex,STRINGDB

SORL1

Tbio

Novelty:  0.00380895

p_int:  0.953990147

p_ni:  0.046009853

Score:  0.206

Data Source:  BioPlex,STRINGDB

LDLR

Tchem

Novelty:  0.06585434

Score:  0.983

Data Source:  STRINGDB

SCAP

Tbio

Novelty:  0.01021709

Score:  0.973

Data Source:  Reactome,STRINGDB

MBTPS2

Tbio

Family:  Enzyme

Novelty:  0.00625665

Score:  0.973

Data Source:  Reactome,STRINGDB

MTOR

Tclin

Family:  Kinase

Novelty:  0.00012333

Score:  0.972

Data Source:  STRINGDB

HMGCS1

Tchem

Family:  Enzyme

Novelty:  0.01089288

Score:  0.97

Data Source:  STRINGDB

MBTPS1

Tchem

Family:  Enzyme

Novelty:  0.00845881

Score:  0.956

Data Source:  Reactome,STRINGDB

EP300

Tchem

Family:  Epigenetic

Novelty:  0.00055009

Score:  0.955

Data Source:  STRINGDB

FASN

Tchem

Family:  Enzyme

Novelty:  0.00142172

Score:  0.954

Data Source:  STRINGDB

Nearest Tclin Targets (5)

Explore Nearest Tclin Targets

Upstream (3)

Downstream (2)

1 – 3 of 3

PIK3CD

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  4

1: Insulin resistance

2: Non-alcoholic fatty liver disease (NAFLD)

3: AMPK signaling pathway

4: Insulin signaling pathway

PIK3CA

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  4

1: Insulin resistance

2: Non-alcoholic fatty liver disease (NAFLD)

3: AMPK signaling pathway

4: Insulin signaling pathway

ADRA1A

Tclin

Family:  GPCR

KEGG Distance:  2

Common Pathways:  1

1: AMPK signaling pathway

Pathways (38)

Reactome (16)

KEGG (4)

PathwayCommons (4)

WikiPathways (14)

Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of gene expression by SREBF (SREBP)	42 targets	R-HSA-2426168
Reactome	Circadian Clock	69 targets	R-HSA-400253
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	FOXO-mediated transcription	68 targets	R-HSA-9614085
Reactome	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	30 targets	R-HSA-9615017

Name	Explore in Pharos	Explore in Source
Activation of gene expression by SREBF (SREBP)	42 targets	R-HSA-2426168
Circadian Clock	69 targets	R-HSA-400253
Developmental Biology	1055 targets	R-HSA-1266738
FOXO-mediated transcription	68 targets	R-HSA-9614085
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	30 targets	R-HSA-9615017

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (55)

Functions (13)

Components (11)

Processes (31)

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Items per page:

10

1 – 10 of 13

GO Term	Evidence	Assigned by
DNA-binding transcription activator activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	BHF-UCL
DNA-binding transcription factor activity	Inferred from Direct Assay (IDA)	HGNC
nuclear receptor activity	Inferred from Direct Assay (IDA)	ParkinsonsUK-UCL
RNA polymerase II regulatory region sequence-specific DNA binding	Inferred from Direct Assay (IDA)	ParkinsonsUK-UCL
sterol response element binding	Inferred from Direct Assay (IDA)	HGNC
DNA binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
chromatin binding	Inferred from Electronic Annotation (IEA)	Ensembl
enzyme activator activity	Inferred from Electronic Annotation (IEA)	Ensembl
protein dimerization activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (25)

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5

1 – 5 of 25

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
waist-hip ratio	EFO_0004343	2	7	7		89.1
BMI-adjusted waist-hip ratio	EFO_0007788	2	7	7		88.2
lymphocyte count	EFO_0004587	2	2	2		86.8
sex hormone-binding globulin measurement	EFO_0004696	2	1	2		81.9
type II diabetes mellitus	EFO_0001360	4	3	3	1.1	77.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
waist-hip ratio	EFO_0004343	7		89.1
BMI-adjusted waist-hip ratio	EFO_0007788	7		88.2
lymphocyte count	EFO_0004587	2		86.8
sex hormone-binding globulin measurement	EFO_0004696	2		81.9
type II diabetes mellitus	EFO_0001360	3	1.1	77.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Activator
Alternative splicing
Cholesterol metabolism
Complete proteome
Cytoplasmic vesicle
Direct protein sequencing
DNA-binding
Endoplasmic reticulum
Golgi apparatus

GWAS Trait Find Similar Targets

No Header	No Header
alcohol consumption measurement
attention deficit hyperactivity disorder
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
body mass index
bone density
coffee consumption measurement
eosinophil count
glomerular filtration rate
HbA1c measurement

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype
liver/biliary system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	sterol regulatory element binding transcription factor 1		706972
Mouse	sterol regulatory element binding transcription factor 1	MGI:107606	20787
Rat	sterol regulatory element binding transcription factor 1	RGD:69423	78968
Dog	sterol regulatory element binding transcription factor 1	VGNC:46795	403475
Horse	sterol regulatory element binding transcription factor 1	VGNC:23576	100052283

Species	Name	OMA	EggNOG	Inparanoid
Macaque	sterol regulatory element binding transcription factor 1
Mouse	sterol regulatory element binding transcription factor 1
Rat	sterol regulatory element binding transcription factor 1
Dog	sterol regulatory element binding transcription factor 1
Horse	sterol regulatory element binding transcription factor 1

Publication Statistics

PubMed Score 1896.99

PubMed score by year

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PubTator Score 732.53

PubTator score by year

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Related Publications

Text Mined References (320)

GeneRif Annotations (269)

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PMID	Year	Title