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Tbio
POLR2I
DNA-directed RNA polymerase II subunit RPB9

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity). This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221859
  • ENSP00000221859
  • ENSG00000105258

Symbol
  • RPB9
  • hRPB14.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
disease perturbation
0.95
histone modification site profile
0.88
interacting protein
0.84
biological process
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.12   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.12   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (562)
POLR2G
Tbio
Family:  Enzyme
Novelty:  0.01235379
p_int:  0.999549765
p_ni:  0.000444358
p_wrong:  0.000005877
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPRD1B
Tbio
Novelty:  0.0444394
p_int:  0.999442531
p_ni:  0.000516522
p_wrong:  0.000040947
Score:  0.979
Data Source:  BioPlex,STRINGDB
Q6EEV4
Tbio
Family:  Enzyme
Novelty:  0.11413088
p_int:  0.999048197
p_ni:  0.000894833
p_wrong:  0.00005697
Score:  0.752
Data Source:  BioPlex,STRINGDB
PIH1D1
Tbio
Novelty:  0.10737369
p_int:  0.977814033
p_ni:  0.008273029
p_wrong:  0.013912938
Score:  0.781
Data Source:  BioPlex,STRINGDB
GPN3
Tbio
Family:  Enzyme
Novelty:  0.13817794
p_int:  0.97715894
p_ni:  0.00856343
p_wrong:  0.01427763
Score:  0.779
Data Source:  BioPlex,STRINGDB
POLR2E
Tbio
Family:  Enzyme
Novelty:  0.01817288
p_int:  0.967597603
p_ni:  0.013720239
p_wrong:  0.018682159
Score:  0.999
Data Source:  BioPlex,STRINGDB
ELOA2
Tdark
Family:  Enzyme
Novelty:  0.7420148
p_int:  0.90683086
p_ni:  0.093124217
p_wrong:  0.000044923
Score:  0.904
Data Source:  BioPlex,STRINGDB
SYDE1
Tbio
Family:  Enzyme
Novelty:  0.04683299
p_int:  0.889013101
p_ni:  0.109135171
p_wrong:  0.001851728
Score:  0.189
Data Source:  BioPlex,STRINGDB
RNGTT
Tbio
Novelty:  0.01433659
p_int:  0.88687558
p_ni:  0.107971737
p_wrong:  0.005152684
Score:  0.922
Data Source:  BioPlex,STRINGDB
LMO2
Tbio
Novelty:  0.0038279
p_int:  0.883114814
p_ni:  0.114603398
p_wrong:  0.002281787
Score:  0.321
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (74)
Abortive elongation of HIV-1 transcript in the absence of Tat (R-HSA-167242)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 70
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abortive elongation of HIV-1 transcript in the absence of Tat
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
DNA Repair
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Abortive elongation of HIV-1 transcript in the absence of Tat
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
DNA Repair
Developmental Biology
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
21.5
neutrophil percentage of leukocytes
1
1
1
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
21.5
neutrophil percentage of leukocytes
1
3.4
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase II subunit I
VGNC:8296
746261
Macaque
RNA polymerase II subunit I
712412
Mouse
MGI:1917170
69920
Dog
RNA polymerase II subunit I
VGNC:44798
476476
Horse
RNA polymerase II subunit I
VGNC:21681
100051926
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase II subunit I
Macaque
RNA polymerase II subunit I
Mouse
Dog
RNA polymerase II subunit I
Horse
RNA polymerase II subunit I
Publication Statistics
PubMed Score 34.12
PubMed score by year
PubTator Score 8.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title