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Tbio
SERPINB5
Serpin B5

Protein Summary
Description
Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382771
  • ENSP00000372221
  • ENSG00000206075
  • ENST00000489441
  • ENSP00000467158

Symbol
  • PI5
  • PI5
  • maspin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.73
gene perturbation
0.67
biological term
0.61
small molecule perturbation
0.61
microRNA
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 591.67   (req: < 5)
Gene RIFs: 205   (req: <= 3)
Antibodies: 508   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 591.67   (req: >= 5)
Gene RIFs: 205   (req: > 3)
Antibodies: 508   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
1
1
5.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
5.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serpin family B member 5
VGNC:9949
468566
Macaque
serpin family B member 5
700713
Mouse
MGI:109579
20724
Rat
RGD:69342
116589
Dog
serpin family B member 5
VGNC:46031
476177
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serpin family B member 5
Macaque
serpin family B member 5
Mouse
Rat
Dog
serpin family B member 5
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P36952-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (161)
1 – 10 of 161
FCF1
Tdark
Novelty: 0.04202976
p_int: 0.999777778
p_ni: 0.000222219
p_wrong: 3e-9
Data Source: BioPlex
TBC1D22B
Tbio
Novelty: 0.49852962
p_int: 0.99963587
p_ni: 0.00036413
Data Source: BioPlex
GPR18
Tchem
Family: GPCR
Novelty: 0.0178347
p_int: 0.998791707
p_ni: 0.001208293
Data Source: BioPlex
RBM24
Tbio
Novelty: 0.04562076
p_int: 0.998406023
p_ni: 0.001593977
Data Source: BioPlex
MMP14
Tchem
Family: Enzyme
Novelty: 0.00083836
p_int: 0.997872658
p_ni: 0.002127342
Data Source: BioPlex
DDX19B
Tbio
Family: Enzyme
Novelty: 0.0504568
p_int: 0.997774638
p_ni: 0.002225362
Data Source: BioPlex
CCDC82
Tdark
Novelty: 0.48211191
p_int: 0.997732415
p_ni: 0.002267585
Data Source: BioPlex
CDK15
Tchem
Family: Kinase
Novelty: 0.3870338
p_int: 0.997471483
p_ni: 0.002528515
p_wrong: 2e-9
Data Source: BioPlex
EIF2A
Tbio
Novelty: 0.08652858
p_int: 0.996755446
p_ni: 0.003032277
p_wrong: 0.000212276
Score: 0.183
Data Source: BioPlex,STRINGDB
GDF5
Tbio
Novelty: 0.00218118
p_int: 0.995854452
p_ni: 0.004145548
Data Source: BioPlex
Publication Statistics
PubMed Score  591.67

PubMed score by year
PubTator Score  399

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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