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Tbio
LTBR
Tumor necrosis factor receptor superfamily member 3

Protein Summary
Description
Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228918
  • ENSP00000228918
  • ENSG00000111321
  • ENST00000539925
  • ENSP00000440875

Symbol
  • D12S370
  • TNFCR
  • TNFR3
  • TNFRSF3
  • TNFCR
  • TNFR3
  • D12S370
  • TNFR-RP
  • TNFRSF3
  • TNFR2-RP
  • LT-BETA-R
  • TNF-R-III
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.74
virus perturbation
0.72
PubMedID
0.69
tissue sample
0.66
histone modification site profile
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 313.18   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 820   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 313.18   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 820   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
4
6
98
5
4
0
1.1
95.8
monocyte count
2
3
3
95.8
platelet crit
2
6
6
95.6
neutrophil percentage of leukocytes
2
3
3
92.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
6
98
0
1.1
95.8
monocyte count
3
95.8
platelet crit
6
95.6
neutrophil percentage of leukocytes
3
92.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lymphotoxin beta receptor
VGNC:5463
451778
Macaque
lymphotoxin beta receptor
712550
Mouse
MGI:104875
17000
Rat
RGD:1309448
297604
Dog
lymphotoxin beta receptor
VGNC:42860
486728
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lymphotoxin beta receptor
Macaque
lymphotoxin beta receptor
Mouse
Rat
Dog
lymphotoxin beta receptor
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P36941-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Reactome
TNFR2 non-canonical NF-kB pathway
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
TNFR2 non-canonical NF-kB pathway
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (160)
1 – 10 of 160
TCHP
Tbio
Novelty:  0.00053696
p_int:  0.999999993
p_ni:  5e-9
p_wrong:  2e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
PRC1
Tbio
Novelty:  0.0411653
p_int:  0.999999962
p_ni:  3.5e-8
p_wrong:  3e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
HDAC5
Tclin
Family:  Epigenetic
Novelty:  0.00484422
p_int:  0.999999959
p_wrong:  4.1e-8
Score:  0.248
Data Source:  BioPlex,STRINGDB
TNIK
Tchem
Family:  Kinase
Novelty:  0.02681864
p_int:  0.999999936
p_ni:  6.4e-8
Data Source:  BioPlex
TRAF3
Tbio
Novelty:  0.0022525
p_int:  0.999999914
p_ni:  8.5e-8
p_wrong:  1e-9
Score:  0.972
Data Source:  BioPlex,Reactome,STRINGDB
CCDC121
Tdark
Novelty:  1.80941324
p_int:  0.999999888
p_ni:  1e-9
p_wrong:  1.11e-7
Data Source:  BioPlex
CEP95
Tdark
Novelty:  1.18897795
p_int:  0.999999882
p_ni:  3.9e-8
p_wrong:  7.9e-8
Score:  0.159
Data Source:  BioPlex,STRINGDB
SPATS2L
Tbio
Novelty:  0.03619189
p_int:  0.999999881
p_ni:  1.19e-7
Score:  0.181
Data Source:  BioPlex,STRINGDB
SPATS2
Tdark
Novelty:  0.20594325
p_int:  0.999999149
p_ni:  8.51e-7
Data Source:  BioPlex
ODF2
Tbio
Novelty:  0.03203587
p_int:  0.999999067
p_ni:  8.64e-7
p_wrong:  6.8e-8
Data Source:  BioPlex
Publication Statistics
PubMed Score  313.18

PubMed score by year
PubTator Score  175.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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