Tbio LTBR Tumor necrosis factor receptor superfamily member 3

Protein Summary

Description

Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• P36941
• B7Z1D2
• D3DUR2
• F5GXE7

Gene Name

• LTBR

Ensembl ID

• ENST00000228918
• ENSP00000228918
• ENSG00000111321
• ENST00000539925
• ENSP00000440875

Symbol

• D12S370
• TNFCR
• TNFR3
• TNFRSF3
• TNFCR
• TNFR3
• D12S370
• TNFR-RP
• TNFRSF3
• TNFR2-RP
• LT-BETA-R
• TNF-R-III

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.74
virus perturbation	0.72
PubMedID	0.69
tissue sample	0.66
histone modification site profile	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 340.31   (req: < 5)

Gene RIFs: 50   (req: <= 3)

Antibodies: 820   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 340.31   (req: >= 5)

Gene RIFs: 50   (req: > 3)

Antibodies: 820   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0