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Tchem
TGFBR1
TGF-beta receptor type-1

Protein Summary
Description
Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374990
  • ENSP00000364129
  • ENSG00000106799
  • ENST00000374994
  • ENSP00000364133
  • ENST00000552516
  • ENSP00000447297

Symbol
  • ALK5
  • SKR4
  • AAT5
  • ALK5
  • ESS1
  • LDS1
  • MSSE
  • SKR4
  • TBRI
  • ALK-5
  • LDS1A
  • LDS2A
  • TBR-i
  • TGFR-1
  • ACVRLK4
  • tbetaR-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
protein domain
0.92
microRNA
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1387.93   (req: < 5)
Gene RIFs: 282   (req: <= 3)
Antibodies: 551   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1387.93   (req: >= 5)
Gene RIFs: 282   (req: > 3)
Antibodies: 551   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 86
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 463
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0