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Tchem
TGFBR1
TGF-beta receptor type-1

Protein Summary
Description
Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374990
  • ENSP00000364129
  • ENSG00000106799
  • ENST00000374994
  • ENSP00000364133
  • ENST00000552516
  • ENSP00000447297

Symbol
  • ALK5
  • SKR4
  • AAT5
  • ALK5
  • ESS1
  • LDS1
  • MSSE
  • SKR4
  • TBRI
  • ALK-5
  • LDS1A
  • LDS2A
  • TBR-i
  • TGFR-1
  • ACVRLK4
  • tbetaR-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
protein domain
0.92
microRNA
0.88


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1194.53   (req: < 5)
Gene RIFs: 282   (req: <= 3)
Antibodies: 551   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1194.53   (req: >= 5)
Gene RIFs: 282   (req: > 3)
Antibodies: 551   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 86
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 288
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (288)
1 – 10 of 288
CHEMBL1808264
chemical structure image
CHEMBL2385582
chemical structure image
CHEMBL2385596
chemical structure image
CHEMBL3818173
chemical structure image
CHEMBL3341789
chemical structure image
galunisertib
chemical structure image
BIX02189
chemical structure image
compound 15b [PMID: 16539403]
chemical structure image
CHEMBL202887
chemical structure image
CHEMBL424676
chemical structure image
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
67.4
2
2
0
1.1
53.1
age at onset
1
1
0
6
24.4
Myopia
1
1
0
6
24.4
refractive error measurement
1
1
0
6
24.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
67.4
0
1.1
53.1
age at onset
0
6
24.4
Myopia
0
6
24.4
refractive error measurement
0
6
24.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transforming growth factor beta receptor 1
VGNC:4876
472992
Macaque
transforming growth factor beta receptor 1
714952
Mouse
MGI:98728
21812
Rat
RGD:3852
29591
Dog
transforming growth factor beta receptor 1
VGNC:51764
481628
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transforming growth factor beta receptor 1
Macaque
transforming growth factor beta receptor 1
Mouse
Rat
Dog
transforming growth factor beta receptor 1
Protein Structure (33 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P36897-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 33
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (76)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downregulation of TGF-beta receptor signaling
Reactome
Loss of Function of SMAD2/3 in Cancer
Name
Explore in Pharos
Explore in Source
Deubiquitination
Disease
Diseases of signal transduction
Downregulation of TGF-beta receptor signaling
Loss of Function of SMAD2/3 in Cancer
Gene Ontology Terms (97)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (256)
1 – 10 of 256
ACVR1C
Tbio
Family: Kinase
Novelty: 0.01675672
p_int: 0.987006788
p_ni: 0.012993212
Data Source: BioPlex
TGFB3
Tbio
Novelty: 0.00068568
Score: 0.999
Data Source: STRINGDB
FKBP1A
Tclin
Family: Enzyme
Novelty: 0.00116174
Score: 0.998
Data Source: Reactome,STRINGDB
SMAD2
Tbio
Family: TF
Novelty: 0.00040166
Score: 0.997
Data Source: Reactome,STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.996
Data Source: Reactome,STRINGDB
TGFB1
Tchem
Novelty: 0.0001299
Score: 0.996
Data Source: Reactome,STRINGDB
TGFBR2
Tchem
Family: Kinase
Novelty: 0.00085381
Score: 0.995
Data Source: Reactome,STRINGDB
SMAD7
Tbio
Family: TF
Novelty: 0.00116343
Score: 0.991
Data Source: Reactome,STRINGDB
SMAD4
Tbio
Family: TF
Novelty: 0.00047069
Score: 0.991
Data Source: STRINGDB
ENG
Tbio
Novelty: 0.00036729
Score: 0.989
Data Source: STRINGDB
Publication Statistics
PubMed Score  1194.53

PubMed score by year
PubTator Score  658.5

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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