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Tchem
ACVR1B
Activin receptor type-1B

Protein Summary
Description
Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACV ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257963
  • ENSP00000257963
  • ENSG00000135503
  • ENST00000415850
  • ENSP00000397550
  • ENST00000426655
  • ENSP00000390477
  • ENST00000541224
  • ENSP00000442656
  • ENST00000542485
  • ENSP00000442885

Symbol
  • ACVRLK4
  • ALK4
  • ALK4
  • SKR2
  • ACTRIB
  • ACVRLK4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.94
protein domain
0.92
kinase perturbation
0.84
microRNA
0.78


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.35   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 509   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.35   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 509   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
wellbeing measurement
1
1
1
74.5
neuroticism measurement
1
1
1
71
depressive symptom measurement
1
1
1
71
1
1
0
1.1
46.8
1
1
0
1.1
42.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
wellbeing measurement
1
74.5
neuroticism measurement
1
71
depressive symptom measurement
1
71
0
1.1
46.8
0
1.1
42.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
activin A receptor type 1B
VGNC:8312
451911
Macaque
activin A receptor type 1B
696587
Mouse
MGI:1338944
11479
Rat
RGD:735207
29381
Dog
activin A receptor type 1B
VGNC:37562
486537
Species
Name
OMA
EggNOG
Inparanoid
Chimp
activin A receptor type 1B
Macaque
activin A receptor type 1B
Mouse
Rat
Dog
activin A receptor type 1B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P36896-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (21)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Regulation of signaling by NODAL
Reactome
Signal Transduction
Reactome
Signaling by Activin
Reactome
Signaling by NODAL
Name
Explore in Pharos
Explore in Source
Developmental Biology
Regulation of signaling by NODAL
Signal Transduction
Signaling by Activin
Signaling by NODAL
Gene Ontology Terms (41)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
HGNC
Protein-Protein Interactions (109)
1 – 10 of 109
ACVR1C
Tbio
Family: Kinase
Novelty: 0.01675672
p_int: 0.999995449
p_ni: 0.000004551
Score: 0.905
Data Source: BioPlex,STRINGDB
ADGRG5
Tdark
Family: GPCR
Novelty: 0.26575982
p_int: 0.94401744
p_ni: 0.055982554
p_wrong: 6e-9
Data Source: BioPlex
TMEM30B
Tbio
Novelty: 0.26735006
p_int: 0.887065496
p_ni: 0.112934501
p_wrong: 3e-9
Score: 0.159
Data Source: BioPlex,STRINGDB
MRAP2
Tbio
Novelty: 0.0420503
p_int: 0.86341577
p_ni: 0.13658423
Score: 0.179
Data Source: BioPlex,STRINGDB
STK36
Tbio
Family: Kinase
Novelty: 0.0963277
p_int: 0.826515812
p_ni: 0.173482665
p_wrong: 0.000001523
Score: 0.185
Data Source: BioPlex,STRINGDB
SMAD2
Tbio
Family: TF
Novelty: 0.00040166
Score: 0.994
Data Source: Reactome,STRINGDB
SMAD4
Tbio
Family: TF
Novelty: 0.00047069
Score: 0.986
Data Source: STRINGDB
ACVR2B
Tchem
Family: Kinase
Novelty: 0.00555742
Score: 0.984
Data Source: Reactome,STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.984
Data Source: Reactome,STRINGDB
TDGF1
Tbio
Novelty: 0.00527099
Score: 0.983
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  134.35

PubMed score by year
PubTator Score  72.45

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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