Tchem BMPR1A Bone morphogenetic protein receptor type-1A

Protein Summary

Description

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P36894
• A8K6U9
• Q8NEN8
• BMP type-1A receptor

Gene Name

• BMPR1A

Ensembl ID

• ENST00000372037
• ENSP00000361107
• ENSG00000107779
• ENST00000635816
• ENSP00000489707
• ENST00000636056
• ENSP00000490273
• ENST00000638429
• ENSP00000492290

Symbol

• ACVRLK3
• ALK3
• ALK3
• SKR5
• CD292
• ACVRLK3
• 10q23del

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	1
protein domain	0.92
kinase perturbation	0.88
disease perturbation	0.83

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Serine/threonine Protein Kinase Receptor / Bone Morphogenetic Protein Receptor Type-1a

Protein / Receptor / Protein Kinase Receptor / Serine/threonine Protein Kinase Receptor / Bone Morphogenetic Protein Receptor Type-1a

Protein / Receptor / Cytokine Receptor / Tgf-beta Receptor / Bone Morphogenetic Protein Receptor Type-1a

DTO Classes

Protein / Kinase / Protein Kinase / Tkl Group / Stkr Family / Stkr Type 1 Subfamily / Bone Morphogenetic Protein Receptor Type-1a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 291.61   (req: < 5)

Gene RIFs: 89   (req: <= 3)

Antibodies: 732   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 291.61   (req: >= 5)

Gene RIFs: 89   (req: > 3)

Antibodies: 732   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 69

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0