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Tclin
FLT3
Receptor-type tyrosine-protein kinase FLT3

Protein Summary
Description
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane lea ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241453
  • ENSP00000241453
  • ENSG00000122025

Symbol
  • CD135
  • FLK2
  • STK1
  • FLK2
  • STK1
  • CD135
  • FLK-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
biological process
0.98
small molecule
0.95
biological term
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3259.12   (req: < 5)
Gene RIFs: 537   (req: <= 3)
Antibodies: 1452   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3259.12   (req: >= 5)
Gene RIFs: 537   (req: > 3)
Antibodies: 1452   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 918
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (12)
sunitinib
Rendered image for sunitinib
nintedanib
Rendered image for nintedanib
ponatinib
Rendered image for ponatinib
sorafenib
Rendered image for sorafenib
gilteritinib
Rendered image for gilteritinib
midostaurin
Rendered image for midostaurin
fedratinib
Rendered image for fedratinib
cabozantinib
Rendered image for cabozantinib
ceritinib
Rendered image for ceritinib
pexidartinib
Rendered image for pexidartinib
Protein-Protein Interactions (313)
FLT3LG
Tbio
Family:  Enzyme
Novelty:  0.00416025
Score:  0.997
Data Source:  Reactome,STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.971
Data Source:  STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.97
Data Source:  STRINGDB
SPI1
Tbio
Family:  TF
Novelty:  0.00064309
Score:  0.969
Data Source:  STRINGDB
CEBPA
Tbio
Family:  TF
Novelty:  0.00056459
Score:  0.961
Data Source:  STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.956
Data Source:  STRINGDB
PIK3R1
Tchem
Family:  Kinase
Novelty:  0.00179772
Score:  0.949
Data Source:  Reactome,STRINGDB
KITLG
Tbio
Novelty:  0.00036337
Score:  0.948
Data Source:  STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
Score:  0.941
Data Source:  STRINGDB
STAT5B
Tchem
Family:  TF
Novelty:  0.00074178
Score:  0.941
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (32)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
IGF1R signaling cascade
Reactome
IRS-mediated signalling
Reactome
IRS-related events triggered by IGF1R
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
IGF1R signaling cascade
IRS-mediated signalling
IRS-related events triggered by IGF1R
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (48)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
5
8
9
99.7
monocyte percentage of leukocytes
2
7
8
99.6
leukocyte count
2
5
6
98.3
neutrophil count
3
5
6
96.1
myeloid white cell count
2
3
4
96
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
9
99.7
monocyte percentage of leukocytes
8
99.6
leukocyte count
6
98.3
neutrophil count
6
96.1
myeloid white cell count
4
96
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fms related tyrosine kinase 3
VGNC:7288
452508
Macaque
fms related tyrosine kinase 3
721712
Mouse
MGI:95559
14255
Rat
RGD:61308
140635
Dog
fms related tyrosine kinase 3
VGNC:40908
486025
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fms related tyrosine kinase 3
Macaque
fms related tyrosine kinase 3
Mouse
Rat
Dog
fms related tyrosine kinase 3
Publication Statistics
PubMed Score 3259.12
PubMed score by year
PubTator Score 1768.71
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title