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Tchem
PPP1CC
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

Protein Summary
Description
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335007
  • ENSP00000335084
  • ENSG00000186298
  • ENST00000340766
  • ENSP00000341779

Symbol
  • PP1C
  • PP-1G
  • PPP1G
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
co-expressed gene
0.94
protein complex
0.81
cellular component
0.8


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 219.02   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 398   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 219.02   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 398   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
protein phosphatase 1 catalytic subunit gamma
709935
Mouse
MGI:104872
19047
Rat
RGD:3377
24669
Dog
protein phosphatase 1 catalytic subunit gamma
VGNC:52957
403557
Horse
protein phosphatase 1 catalytic subunit gamma
VGNC:50962
100058160
Species
Name
OMA
EggNOG
Inparanoid
Macaque
protein phosphatase 1 catalytic subunit gamma
Mouse
Rat
Dog
protein phosphatase 1 catalytic subunit gamma
Horse
protein phosphatase 1 catalytic subunit gamma
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P36873-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (55)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (39)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (478)
1 – 10 of 478
PPP1R18
Tbio
Novelty: 0.18837599
p_int: 1
Score: 0.402
Data Source: BioPlex,STRINGDB
TPRN
Tbio
Novelty: 0.05784581
p_int: 1
Score: 0.241
Data Source: BioPlex,STRINGDB
ZFYVE9
Tbio
Novelty: 0.00565862
p_int: 0.999999998
p_ni: 2e-9
p_wrong: 1e-9
Score: 0.509
Data Source: BioPlex,Reactome,STRINGDB
PPP1R8
Tbio
Family: Enzyme
Novelty: 0.00138054
p_int: 0.999999997
p_ni: 3e-9
Score: 0.986
Data Source: BioPlex,STRINGDB
KIF18A
Tbio
Novelty: 0.02071108
p_int: 0.999999993
p_ni: 6e-9
p_wrong: 1e-9
Score: 0.971
Data Source: BioPlex,STRINGDB
CDCA2
Tbio
Novelty: 0.04666018
p_int: 0.999999987
p_ni: 1.2e-8
p_wrong: 1e-9
Score: 0.489
Data Source: BioPlex,STRINGDB
SHOC2
Tbio
Novelty: 0.01203957
p_int: 0.999999984
p_ni: 1.3e-8
p_wrong: 3e-9
Score: 0.987
Data Source: BioPlex,STRINGDB
PPP1R9A
Tbio
Novelty: 0.04851082
p_int: 0.999999969
p_ni: 3.1e-8
Score: 0.618
Data Source: BioPlex,STRINGDB
LMTK2
Tbio
Family: Kinase
Novelty: 0.02138451
p_int: 0.999999967
p_ni: 2e-9
p_wrong: 3.1e-8
Score: 0.743
Data Source: BioPlex,STRINGDB
ZFYVE16
Tbio
Novelty: 0.10765234
p_int: 0.999999954
p_ni: 2.7e-8
p_wrong: 2e-8
Score: 0.745
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  219.02

PubMed score by year
PubTator Score  74.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer