PGM1
Phosphoglucomutase-1
Protein Summary
This enzyme participates in both the breakdown and synthesis of glucose. The protein encoded by this gene is an isozyme of phosphoglucomutase (PGM) and belongs to the phosphohexose mutase family. There are several PGM isozymes, which are encoded by different genes and catalyze the transfer of phosphate between the 1 and 6 positions of glucose. In most cell types, this PGM isozyme is predominant, representing about 90% of total PGM activity. In red cells, PGM2 is a major isozyme. This gene is highly polymorphic. Mutations in this gene cause glycogen storage disease type 14. Alternativley spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Mar 2010]
- ENST00000371083
- ENSP00000360124
- ENSG00000079739
- ENST00000371084
- ENSP00000360125
- ENST00000540265
- ENSP00000443449
- CDG1T
- GSD14
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
protein domain | 0.92 | ||
kinase perturbation | 0.91 | ||
ligand (protein) perturbation | 0.83 | ||
histone modification site profile | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 647.99 (req: < 5)
Gene RIFs: 32 (req: <= 3)
Antibodies: 215 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 647.99 (req: >= 5)
Gene RIFs: 32 (req: > 3)
Antibodies: 215 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0