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Tbio
LONP1
Lon protease homolog, mitochondrial

Protein Summary
Description
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:12198491, PubMed:15870080, PubMed:17420247, PubMed:8248235). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, helicase Twinkle (TWNK) and the large ribosomal subunit protein bL32m. bL32m is prot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360614
  • ENSP00000353826
  • ENSG00000196365
  • ENST00000540670
  • ENSP00000441523
  • ENST00000593119
  • ENSP00000468541

Symbol
  • PRSS15
  • LON
  • LONP
  • PIM1
  • hLON
  • LonHS
  • CODASS
  • PRSS15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
interacting protein
0.99
transcription factor binding site profile
0.93
kinase perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 298.86   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 298.86   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
76.2
mean corpuscular volume
1
1
1
30.6
red blood cell distribution width
1
1
1
26.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
76.2
mean corpuscular volume
1
30.6
red blood cell distribution width
1
26.3
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (30)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Protein-Protein Interactions (124)
1 – 10 of 124
KLHDC8A
Tdark
Novelty: 1.43751731
p_int: 0.995814537
p_ni: 0.004185463
Data Source: BioPlex
DALRD3
Tdark
Novelty: 0.5378666
p_int: 0.983929255
p_ni: 0.016070745
Score: 0.154
Data Source: BioPlex,STRINGDB
GCAT
Tbio
Family: Enzyme
Novelty: 0.00503538
p_int: 0.972037857
p_ni: 0.027962142
p_wrong: 1e-9
Score: 0.543
Data Source: BioPlex,STRINGDB
TEX45
Tdark
Novelty: 5.55785981
p_int: 0.965512882
p_ni: 0.034487118
Score: 0.186
Data Source: BioPlex,STRINGDB
STPG3
Tdark
Novelty: 1.88764045
p_int: 0.95230837
p_ni: 0.04769163
Score: 0.536
Data Source: BioPlex,STRINGDB
RASL10B
Tdark
Family: Enzyme
Novelty: 0.36095886
p_int: 0.927556729
p_ni: 0.072443271
Data Source: BioPlex
DCAF12L2
Tdark
Novelty: 2.92107204
p_int: 0.926438408
p_ni: 0.073561592
Score: 0.158
Data Source: BioPlex,STRINGDB
MRM2
Tbio
Family: Enzyme
Novelty: 0.06394065
p_int: 0.912108492
p_ni: 0.087891508
Score: 0.246
Data Source: BioPlex,STRINGDB
MRPL4
Tdark
Novelty: 0.27290276
p_int: 0.89536972
p_ni: 0.10463028
Score: 0.313
Data Source: BioPlex,STRINGDB
DCAF4
Tbio
Novelty: 0.24190895
p_int: 0.855930588
p_ni: 0.144069412
Data Source: BioPlex
Publication Statistics
PubMed Score  298.86

PubMed score by year
PubTator Score  241.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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