Tchem NUDT1 7,8-dihydro-8-oxoguanine triphosphatase

Protein Summary

Description

Antimutagenic (PubMed:8226881, PubMed:7713500, PubMed:10608900). Plays a redundant role in sanitizing oxidized nucleotide pools, such as 8-oxo-dGTP pools (PubMed:28679043). Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress (PubMed:12857738, PubMed:24695224, PubMed:24695225). Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions (PubMed:8226881, PubMed:10373420, PubMed:10608900, PubMed:11756418, PubMed:12857738, PubMed:16607562, PubMed:24695224, PubMed:24695225, PubMed:26999531, PubMed:28035004). Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP (PubMed:10373420, PubMed:11139615). Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity). Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A rare single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Dec 2018]

Uniprot Accession IDs

• P36639
• A4D205
• Q6LES7
• Q6P0Y6
• Q7Z7N6
• Q8IV95
• Q9UBM0
• Q9UBM9

Gene Name

• NUDT1

Ensembl ID

• ENST00000339737
• ENSP00000343439
• ENSG00000106268
• ENST00000343985
• ENSP00000339503
• ENST00000356714
• ENSP00000349148
• ENST00000397046
• ENSP00000380239
• ENST00000397048
• ENSP00000380241
• ENST00000397049
• ENSP00000380242

Symbol

• MTH1
• MTH1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.87
co-expressed gene	0.85
histone modification site profile	0.82
molecular function	0.81
transcription factor binding site profile	0.74

Protein Classes

PANTHER Classes

Protein / Transferase / Phosphorylase / 7,8-dihydro-8-oxoguanine Triphosphatase

Protein / Hydrolase / 7,8-dihydro-8-oxoguanine Triphosphatase

DTO Classes

Protein / Enzyme / Transferase / Phosphorylase / 7,8-dihydro-8-oxoguanine Triphosphatase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 312.89   (req: < 5)

Gene RIFs: 84   (req: <= 3)

Antibodies: 216   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 312.89   (req: >= 5)

Gene RIFs: 84   (req: > 3)

Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 104

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1