You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
NUDT1
7,8-dihydro-8-oxoguanine triphosphatase

Protein Summary
Description
Antimutagenic (PubMed:8226881, PubMed:7713500, PubMed:10608900). Plays a redundant role in sanitizing oxidized nucleotide pools, such as 8-oxo-dGTP pools (PubMed:28679043). Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress (PubMed:12857738, PubMed:24695224, PubMed:24695225). Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions (PubMed:8226881, PubMed:10373420, PubMed:10608900, PubMed:11756418, PubMed:12857738, PubMed:16607562, PubMed:24695224, PubMed:24695225, PubMed:26999531, PubMed:28035004). Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP (PubMed:10373420, PubMed:11139615). Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity). Misincorporation of oxidized nucleoside triphosphates ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339737
  • ENSP00000343439
  • ENSG00000106268
  • ENST00000343985
  • ENSP00000339503
  • ENST00000356714
  • ENSP00000349148
  • ENST00000397046
  • ENSP00000380239
  • ENST00000397048
  • ENSP00000380241
  • ENST00000397049
  • ENSP00000380242

Symbol
  • MTH1
  • MTH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.87
co-expressed gene
0.85
histone modification site profile
0.82
molecular function
0.81
transcription factor binding site profile
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.72   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.72   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 88
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (88)
1 – 10 of 88
alpha-mangostin
Rendered image for alpha-mangostin
SID4252862
Rendered image for SID4252862
CHEMBL4436749
Rendered image for CHEMBL4436749
CHEMBL4570266
Rendered image for CHEMBL4570266
CHEMBL4083992
Rendered image for CHEMBL4083992
CHEMBL4070624
Rendered image for CHEMBL4070624
CHEMBL4460228
Rendered image for CHEMBL4460228
CHEMBL4435945
Rendered image for CHEMBL4435945
CHEMBL4529335
Rendered image for CHEMBL4529335
Protein-Protein Interactions (81)
1 – 10 of 81
SPIN3
Tchem
Novelty:  0.16670763
p_int:  0.999898294
p_ni:  0.000101706
Score:  0.393
Data Source:  BioPlex,STRINGDB
WDFY1
Tbio
Novelty:  0.13382544
p_int:  0.998806585
p_ni:  0.001191747
p_wrong:  0.000001668
Data Source:  BioPlex
ACY1
Tbio
Family:  Enzyme
Novelty:  0.00912344
p_int:  0.985750564
p_ni:  0.013997734
p_wrong:  0.000251703
Score:  0.799
Data Source:  BioPlex,STRINGDB
RRAGB
Tbio
Novelty:  0.02279777
p_int:  0.94390068
p_ni:  0.05400283
p_wrong:  0.00209649
Score:  0.199
Data Source:  BioPlex,STRINGDB
NUDT5
Tbio
Family:  Enzyme
Novelty:  0.02550535
Score:  0.865
Data Source:  STRINGDB
MUTYH
Tbio
Family:  Enzyme
Novelty:  0.00137239
Score:  0.823
Data Source:  STRINGDB
OGG1
Tchem
Family:  Enzyme
Novelty:  0.00074509
Score:  0.814
Data Source:  STRINGDB
NUDT15
Tbio
Family:  Enzyme
Novelty:  0.008497
Score:  0.795
Data Source:  STRINGDB
NUDT12
Tbio
Family:  Enzyme
Novelty:  0.18740719
Score:  0.74
Data Source:  STRINGDB
ATOX1
Tbio
Novelty:  0.00509938
Score:  0.726
Data Source:  STRINGDB
Pathways (6)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Phosphate bond hydrolysis by NUDT proteins
Reactome
Purine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Phosphate bond hydrolysis by NUDT proteins
Purine catabolism
Gene Ontology Terms (28)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
plasminogen activator inhibitor 1 measurement
2
3
0
545
92
self reported educational attainment
2
3
3
91.1
serum albumin measurement
1
2
2
90.3
mathematical ability
2
3
3
85.8
blood protein measurement
1
1
1
84.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
plasminogen activator inhibitor 1 measurement
0
545
92
self reported educational attainment
3
91.1
serum albumin measurement
2
90.3
mathematical ability
3
85.8
blood protein measurement
1
84.9
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nudix hydrolase 1
VGNC:4451
463225
Macaque
nudix hydrolase 1
713078
Mouse
MGI:109280
17766
Rat
RGD:621080
117260
Dog
nudix hydrolase 1
VGNC:44024
489894
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nudix hydrolase 1
Macaque
nudix hydrolase 1
Mouse
Rat
Dog
nudix hydrolase 1
Publication Statistics
PubMed Score 271.72
PubMed score by year
PubTator Score 175.47
PubTator score by year