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Tbio
RPL4
60S ribosomal protein L4

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L4E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307961
  • ENSP00000311430
  • ENSG00000174444

Symbol
  • RPL1
  • L4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
hub protein
0.94
kinase perturbation
0.93
protein complex
0.82


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.43   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.43   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (568)
CNBP
Tbio
Novelty:  0.00404247
p_int:  0.981251568
p_ni:  0.018748432
Score:  0.674
Data Source:  BioPlex,STRINGDB
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.963668396
p_ni:  0.036331604
Score:  0.845
Data Source:  BioPlex,STRINGDB
RPL28
Tbio
Novelty:  0.03136035
p_int:  0.960572518
p_ni:  0.039427482
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPL37A
Tbio
Novelty:  0.03475061
p_int:  0.950344772
p_ni:  0.049655228
Score:  0.999
Data Source:  BioPlex,STRINGDB
MAGEB10
Tdark
Novelty:  2.96156972
p_int:  0.932671984
p_ni:  0.067328016
Data Source:  BioPlex
MAK16
Tdark
Novelty:  0.07717917
p_int:  0.92543365
p_ni:  0.07456635
Score:  0.776
Data Source:  BioPlex,STRINGDB
RPL30
Tbio
Novelty:  0.0134194
p_int:  0.895196669
p_ni:  0.104803331
Score:  0.999
Data Source:  BioPlex,STRINGDB
H1FOO
Tbio
Novelty:  0.02189067
p_int:  0.893228099
p_ni:  0.106771901
Data Source:  BioPlex
PUM3
Tbio
Novelty:  0.02344206
p_int:  0.879879423
p_ni:  0.120120577
Score:  0.813
Data Source:  BioPlex,STRINGDB
NOP53
Tbio
Novelty:  0.00353077
p_int:  0.873774823
p_ni:  0.126225177
Score:  0.799
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (35)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
2
3
87.5
triglyceride measurement
3
2
3
63.6
mean platelet volume
1
1
1
56.4
mathematical ability
1
1
1
56.4
body mass index
1
1
1
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
87.5
triglyceride measurement
3
63.6
mean platelet volume
1
56.4
mathematical ability
1
56.4
body mass index
1
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L4
VGNC:1885
748261
Macaque
ribosomal protein L4
710590
Mouse
MGI:1915141
67891
Rat
RGD:619824
64302
Dog
ribosomal protein L4
609491
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L4
Macaque
ribosomal protein L4
Mouse
Rat
Dog
ribosomal protein L4
Publication Statistics
PubMed Score 197.43
PubMed score by year
PubTator Score 350.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title